Description

13-Cis Retinoic Acid-D5 Methyl Ester is a stable isotope-labeled analog of the biologically active retinoid, isotretinoin. This deuterated compound is specifically designed for use as an internal standard in quantitative mass spectrometry, providing superior accuracy and reliability in analytical workflows. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors who require precise measurement of retinoid compounds in complex matrices.

Application

• Internal Standard for LC-MS/MS: Primary application for the quantitative analysis of isotretinoin (13-cis retinoic acid) and related metabolites in pharmacokinetic and bioequivalence studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track and quantify the parent drug and its derivatives.
• Clinical Research: Enables accurate monitoring of isotretinoin levels in patient plasma or serum during treatment for severe acne or other dermatological conditions.
• Pharmaceutical Quality Control: Supports assay development and validation for the potency and purity testing of isotretinoin-based drug products.
• Biomarker Research: Facilitates the precise quantification of retinoid signaling molecules in studies of cellular differentiation and oncology.
• Forensic Toxicology: Aids in the confirmatory analysis of isotretinoin in forensic casework.

Basic Information

Product Name	13-Cis Retinoic Acid-D5 Methyl Ester
CAS No.	1331666-29-5
Molecular Formula	C21H23D5O2
Molecular Weight	~329.5 g/mol
Synonyms	Isotretinoin-d5 Methyl Ester; 13-cis-Retinoic Acid-d5 Methyl Ester; (2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid-d5 Methyl Ester; Ro 4-3780-d5 Methyl Ester; Accutane-d5 Methyl Ester; 13-Cis Vitamin A Acid-d5 Methyl Ester
EINECS	Contact for details

Quality Control

Our 13-Cis Retinoic Acid-D5 Methyl Ester is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic enrichment (≥98 atom % D), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation. The material is light-sensitive and should be handled under subdued lighting conditions.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Solubility	Soluble in DMSO, methanol, chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.