Description

2-Amino-α-(Methoxyimino)-4-Thiazoleacetic Acid-D3 is a deuterium-labeled analog of a key thiazoleacetic acid derivative, serving as a critical stable isotope-labeled internal standard. This compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry analyses, particularly in regulated environments. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers for pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of its non-deuterated counterpart in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Critical in drug discovery and development for conducting accurate Absorption, Distribution, Metabolism, and Excretion (ADME) studies.
• Bioanalytical Method Validation: Employed to develop and validate robust, sensitive, and specific analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Metabolite Identification & Profiling: Aids in the identification and structural elucidation of drug metabolites using mass spectrometry.
• Clinical Trial Support: Provides reliable data for pharmacokinetic and pharmacodynamic evaluations during clinical phases of drug development.
• Quality Control in API Manufacturing: Can be used in analytical quality control to monitor the presence and quantity of specific related substances.

Basic Information

Product Name	2-Amino-α-(Methoxyimino)-4-Thiazoleacetic Acid-D3
CAS No.	1331655-54-9
Molecular Formula	C7H6D3N3O3S
Molecular Weight	218.24 g/mol (for deuterated form)
Synonyms	2-Amino-α-(methoxyimino)-4-thiazoleacetic-2,2,2-d3 acid; (Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetic-2,2,2-d3 acid; Deuterated 2-(2-Aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetic acid; 2-(2-Aminothiazol-4-yl)-2-[(Z)-methoxyimino]acetic-2,2,2-d3 acid; ATMA-d3; Cefotaxime Impurity D3 (related compound); Stable Isotope Labeled Thiazole Acetic Acid Derivative
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-α-(Methoxyimino)-4-Thiazoleacetic Acid-D3 is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use in regulated research, including Chemical Purity (HPLC), Isotopic Enrichment (NMR/MS), and confirmation of structure and deuteration position. Certificates of Analysis (COA) detailing all specifications and test results are available upon request and are essential for audit and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.