Description

(1S,2S)-2-[2-Hydroxyethyl(Trideuteriomethyl)Amino]-1-Phenylpropan-1-Ol is a deuterated chiral compound of significant interest in advanced pharmaceutical research and development. Its core value lies in its utility as a stable isotope-labeled building block, enabling precise metabolic and pharmacokinetic studies. This product is essential for researchers and manufacturers in the pharmaceutical industry, particularly those developing and analyzing novel active pharmaceutical ingredients (APIs) where deuterium labeling is used to modify drug metabolism and improve therapeutic profiles.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quality control and analytical method validation of deuterated APIs.
• Metabolic Tracing Studies: Used as a stable isotope-labeled tracer in mass spectrometry-based assays to investigate drug metabolism pathways and identify metabolites.
• Deuterated Drug Intermediate: Acts as a key chiral synthon in the multi-step synthesis of deuterium-enriched pharmaceutical compounds.
• Pharmacokinetic (PK) Research: Employed in clinical and pre-clinical studies to enhance the detection and quantification of drugs and their metabolites in biological matrices.
• Isotope Effect Investigation: Facilitates research into the kinetic isotope effect (KIE) to understand reaction mechanisms and optimize synthetic routes.
• Internal Standard for Bioanalysis: Provides a highly specific internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) bioanalytical assays, improving accuracy and precision.

Basic Information

Product Name	(1S,2S)-2-[2-Hydroxyethyl(Trideuteriomethyl)Amino]-1-Phenylpropan-1-Ol
CAS No.	1330277-60-5
Molecular Formula	C₁₂H₁₈D₃NO₂
Molecular Weight	210.32 g/mol (for C₁₂H₁₈D₃NO₂)
Synonyms	(1S,2S)-2-[(2-Hydroxyethyl)(trideuteriomethyl)amino]-1-phenyl-1-propanol; (1S,2S)-2-[N-(2-Hydroxyethyl)-N-(trideuteriomethyl)amino]-1-phenylpropan-1-ol; Deuterated Pseudoephedrine Derivative; (1S,2S)-N-Trideuteriomethyl-N-(2-hydroxyethyl)phenylpropanolamine; d3-(1S,2S)-2-(N-Methyl-N-2-hydroxyethylamino)-1-phenyl-1-propanol; (1S,2S)-2-[(2-Hydroxyethyl)(methyl-d3)amino]-1-phenylpropan-1-ol
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C, ²H), High-Resolution Mass Spectrometry (HRMS), and Chiral HPLC analysis to confirm structural identity, isotopic purity (D-enrichment), and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR)	≥ 98 atom % D
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.