Description

4-Amino-2,3,5,6-Tetradeuterio-n-(5,6-Dimethoxypyrimidin-4-Yl)Benzenesulfonamide is a high-purity, deuterium-labeled sulfonamide derivative designed for advanced research and development applications. This compound is critical for studies requiring precise isotopic labeling, such as metabolic pathway tracing, pharmacokinetic analysis, and the development of novel analytical methods. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on medicinal chemistry and drug discovery.

Application

• As a deuterated internal standard for the quantitative analysis of pharmaceutical compounds and metabolites using LC-MS/MS and GC-MS.
• In isotope dilution mass spectrometry to ensure accuracy and precision in bioanalytical method development and validation.
• For metabolic stability and drug metabolism studies (DMPK) to track the fate of drug molecules in biological systems.
• As a key chemical reference standard in quality control laboratories for method calibration and verification.
• In medicinal chemistry research for structure-activity relationship (SAR) studies of sulfonamide-based therapeutics.
• For the synthesis of more complex deuterium-labeled probes and intermediates used in mechanistic and diagnostic research.

Basic Information

Product Name	4-Amino-2,3,5,6-Tetradeuterio-n-(5,6-Dimethoxypyrimidin-4-Yl)Benzenesulfonamide
CAS No.	1330266-05-1
Molecular Formula	C12H10D4N4O4S
Molecular Weight	314.36 g/mol
Synonyms	4-Amino-2,3,5,6-tetradeuterio-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide; Deuterated Sulfamethoxazole-d4; Sulfamethoxazole-d4; 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide-2,3,5,6-d4; SMX-d4; 3,4-Dimethoxy-6-sulfanilamidopyrimidine-d4; Benzenesulfonamide, 4-amino-2,3,5,6-tetradeuterio-N-(5,6-dimethoxy-4-pyrimidinyl)-
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced and analyzed under strict quality management to ensure isotopic purity and chemical integrity. We provide comprehensive Certificates of Analysis (COA) detailing results from NMR (¹H, ¹³C), mass spectrometry, and HPLC for chemical and isotopic purity. Our quality systems support compliance with the standards required for GLP and research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Incorporation)	≥98 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.