Description

Ramosetron-D3 Hydrochloride is a deuterated isotopologue of the potent and selective 5-HT3 receptor antagonist Ramosetron, specifically labeled with three deuterium atoms. This high-purity reference standard is critical for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is an essential material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in the development and validation of assays for Ramosetron.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the precise quantification of Ramosetron in complex biological matrices (e.g., plasma, serum, urine) using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) by correcting for matrix effects and instrument variability.
• Bioanalytical Method Development & Validation: Serves as a critical component in developing, optimizing, and validating robust, GLP-compliant analytical methods for clinical and non-clinical studies.
• Drug Impurity Profiling: Used as a reference marker in stability studies and impurity characterization to understand degradation pathways.
• Regulatory Submissions: Supports data packages submitted to regulatory agencies (e.g., FDA, EMA) by providing traceable and definitive quantification of the active pharmaceutical ingredient.

Basic Information

Product Name	Ramosetron-D3 Hydrochloride
CAS No.	1330266-04-0
Molecular Formula	C₁₇H₁₄D₃N₃O•HCl
Molecular Weight	316.82 g/mol (approx.)
Synonyms	(1-Methyl-1H-indazol-3-yl)methyl (4R,5S)-7-methyl-3-(5-methyl-1H-imidazol-4-yl)-2,4-diazabicyclo[3.3.0]oct-2-ene-4-carboxylate-d3 hydrochloride; Ramosetron-d3 HCl; Ramosetron (methyl-d3) hydrochloride; YM060-d3 hydrochloride; Deuterated Ramosetron Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Ramosetron-D3 Hydrochloride is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, confirmed by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and all specification results is provided with each shipment to ensure full traceability and compliance with your research or quality control protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (deuterium content)	≥99.0 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.