Description

3-Carboxy-α-Methyl-Benzeneacetic Acid-D3 is a deuterated analog of a key pharmaceutical intermediate, offering a stable isotope-labeled standard essential for precise analytical quantification. This compound is critical for ensuring accuracy and reliability in mass spectrometry and metabolic studies, where distinguishing between endogenous and exogenous compounds is paramount. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug development, pharmacokinetics, and advanced material science.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial reference standard in quantitative bioanalytical methods for drug metabolism and pharmacokinetic (DMPK) studies.
• Pharmaceutical Intermediate: Used in the synthesis of deuterated drug candidates, leveraging the kinetic isotope effect for improved metabolic stability.
• Metabolic Pathway Tracing: Enables detailed investigation of biochemical pathways and metabolite identification in biomedical research.
• Quality Control & Method Validation: Essential for developing and validating robust analytical methods in regulatory environments (e.g., FDA, EMA submissions).
• Stable Isotope Labeling: Applied in the preparation of labeled compounds for use as probes in various spectroscopic and mechanistic studies.

Basic Information

Product Name	3-Carboxy-α-Methyl-Benzeneacetic Acid-D3
CAS No.	1330265-71-8
Molecular Formula	C10H7D3O4
Molecular Weight	197.20 g/mol
Synonyms	2-(3-Carboxyphenyl)propionic-2,3,3-d3 acid; 2-(3-Carboxyphenyl)propionic-d3 acid; 3-Carboxy-α-methylbenzeneacetic-d3 acid; Deuterated Diclofenac Impurity/Intermediate; (3-Carboxyphenyl)-d3-acetic acid, α-methyl-; 2-(3-Carboxy-d3-phenyl)propionic acid; m-Carboxyhydratropic-d3 acid
EINECS	Contact for details

Quality Control

Every batch of 3-Carboxy-α-Methyl-Benzeneacetic Acid-D3 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high chemical purity and isotopic enrichment. Our quality assurance protocols are designed to meet the stringent requirements of research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, isotopic purity (D-enrichment), and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and deuterium labeling pattern
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.