Description

Sertaconazole-D6 is a deuterium-labeled analog of the antifungal agent sertaconazole, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS, by correcting for variations in sample preparation and instrument response. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities engaged in drug metabolism, pharmacokinetic studies, and bioanalytical method development.

Application

• Primary use as an internal standard for the quantification of sertaconazole in biological matrices (plasma, serum, tissue) via LC-MS/MS.
• Critical component in pharmacokinetic (PK) and bioequivalence studies for antifungal drug development.
• Enables precise drug metabolism and disposition (DMPK) research by providing a stable isotopic reference.
• Supports the development and validation of regulatory-compliant bioanalytical methods for GLP and clinical studies.
• Used in forensic and anti-doping analysis for the accurate detection of sertaconazole.
• Facilitates impurity profiling and stability-indicating assays in pharmaceutical quality control.

Basic Information

Product Name	Sertaconazole-D6
CAS No.	1330261-47-6
Molecular Formula	C20H15D6Cl3N2OS
Molecular Weight	437.82 g/mol (approx.)
Synonyms	1-[2-(7-Chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole-d6; (+-)-Sertaconazole-d6; Sertaconazole (hexadeuterated); Sertaconazole D6; Sertaconazole Internal Standard; 7-Chloro-3-[(1RS)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl-d6)ethoxy]benzo[b]thiophene
EINECS	Contact for details

Quality Control

Our Sertaconazole-D6 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic techniques (NMR, MS) and chromatographic methods (HPLC, UPLC) to confirm identity, isotopic enrichment (typically ≥98 atom % D), and chemical purity (typically ≥95%). A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment, supporting compliance with GLP and other regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.