Description

Rabeprazole Sulfone-D3 is a deuterium-labeled analog of the Rabeprazole Sulfone metabolite, a key compound in pharmaceutical research and development. This high-purity stable isotope-labeled standard is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily utilized by analytical laboratories and pharmaceutical companies engaged in drug metabolism and pharmacokinetic (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of rabeprazole and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used to investigate the metabolic pathways, clearance rates, and bioavailability of rabeprazole in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Essential for developing and validating robust, sensitive, and specific HPLC or UPLC-MS/MS methods in compliance with GLP and FDA guidelines.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Enables accurate measurement of drug concentration over time to establish dose-response relationships.
• Clinical Trial Support: Provides reliable data for bioequivalence studies and therapeutic drug monitoring during clinical trials.
• Reference Standard for Impurity Testing: Can be used as a reference marker for identifying and quantifying related substances or degradation products in active pharmaceutical ingredient (API) quality control.

Basic Information

Product Name	Rabeprazole Sulfone-D3
CAS No.	1330261-33-0
Molecular Formula	C18H17D3N3O3S
Molecular Weight	359.45 g/mol
Synonyms	2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole-d3 Sulfone; Deuterated Rabeprazole Sulfone; Rabeprazole Sulfone (methyl-d3); Rabeprazole-d3 Sulfone; 1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-, 1,2,3-d3-, 1-oxide
EINECS	Contact for details

Quality Control

Our Rabeprazole Sulfone-D3 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and purity by HPLC. We support research requiring compliance with cGMP, GLP, and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (deuterium, D3)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.