Description

Buthiazide-D10 (Major) is a high-purity, deuterium-labeled internal standard essential for precise quantitative analysis. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in mass spectrometry-based methods, eliminating matrix effects and instrumental variability. It is primarily required by analytical laboratories and pharmaceutical R&D teams engaged in method development, pharmacokinetic studies, and regulatory compliance testing for the parent drug, Buthiazide.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for bioanalytical studies of Buthiazide.
• Pharmacokinetic & Metabolism Research: Enables accurate tracking and quantification of Buthiazide and its metabolites in biological matrices (plasma, urine, tissue).
• Method Development & Validation: Serves as a critical component in developing and validating robust, GLP-compliant analytical methods.
• Drug Impurity Profiling: Assists in the identification and quantification of process-related impurities and degradants in pharmaceutical formulations.
• Clinical Trial Support: Provides reliable data for drug concentration monitoring in human clinical trials.
• Forensic & Doping Analysis: Applied in specialized testing where precise quantification of diuretic agents is required.

Basic Information

Product Name	Buthiazide-D10 (Major)
CAS No.	1330189-19-9
Molecular Formula	C11H6D10ClN3O4S2
Molecular Weight	Approx. 357.4 g/mol
Synonyms	6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-d10; Deuterated Buthiazide; Buthiazide-d10; Buthiazide (phenyl-d5, chlorophenyl-d5); 3-(4-Chloro-3-sulfamoylphenyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-d10; Buthiazide Internal Standard; Buthiazide Stable Isotope.
EINECS	Contact for details

Quality Control

Every batch of Buthiazide-D10 (Major) is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical purity and NMR/MS for isotopic enrichment and positional confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. The container should be allowed to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.