Description

8-(4-Bromobutyl)-8-Azaspiro[4.5]Decane-7,9-Dione-D8 is a deuterated analog of a key spirocyclic glutarimide intermediate. This compound is specifically designed for use as a stable isotope-labeled internal standard in analytical chemistry, providing critical support for method development and validation. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require high-purity, isotopically labeled building blocks for synthesis, metabolism studies, and quantitative mass spectrometry.

Application

• Primary use as a stable isotope-labeled internal standard (IS) for the quantification of its non-deuterated counterpart in complex matrices via LC-MS/MS.
• Key deuterated building block in the synthesis of novel pharmaceutical compounds, particularly for neurological and psychiatric drug discovery programs.
• Critical reagent in metabolism and pharmacokinetic (DMPK) studies to trace the absorption, distribution, metabolism, and excretion of active pharmaceutical ingredients.
• Used in the development of highly sensitive and specific analytical methods for quality control and impurity profiling in API manufacturing.
• Valuable intermediate for agrochemical research, aiding in the development and analysis of new active ingredients.

Basic Information

Product Name	8-(4-Bromobutyl)-8-Azaspiro[4.5]Decane-7,9-Dione-D8
CAS No.	1330189-17-7
Molecular Formula	C₁₃H₁₃D₈BrNO₂
Molecular Weight	328.27 g/mol (for deuterated form)
Synonyms	8-(4-Bromobutyl)-8-azaspiro[4.5]decane-7,9-dione-d8; Deuterated 8-(4-Bromobutyl)-8-azaspiro[4.5]decane-7,9-dione; 8-Azaspiro[4.5]decane-7,9-dione, 8-(4-bromobutyl)-, d8; Spiroglutarimide-d8 bromobutyl derivative; Isotope-labeled spirocyclic glutarimide; (D8)-8-(4-Bromobutyl)-8-azaspiro[4.5]decane-7,9-dione
EINECS	Contact for details

Quality Control

Every batch of 8-(4-Bromobutyl)-8-Azaspiro[4.5]Decane-7,9-Dione-D8 is produced and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, with specifications tailored to meet the rigorous demands of analytical and synthetic applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as assay (HPLC), isotopic purity (NMR/MS), and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.