Description

1-Benzhydrylpiperazine-D8 is a deuterated analog of benzhydrylpiperazine, a key building block in medicinal chemistry and pharmaceutical research. This isotopically labeled compound is specifically designed for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in pharmacokinetic and metabolic studies. It is an essential tool for researchers and developers in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require high-purity, stable-labeled standards for advanced analytical applications.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the precise quantification of benzhydrylpiperazine and its derivatives in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for studying absorption, distribution, metabolism, and excretion (ADME) profiles of drug candidates during preclinical and clinical development stages.
• Forensic and Clinical Toxicology: Used in analytical methods for the accurate detection and measurement of specific pharmaceuticals or metabolites in forensic and diagnostic testing.
• Biomedical Research: Enables detailed mechanistic studies of drug action and biochemical pathways where the parent compound is involved.
• Pharmaceutical Quality Control: Supports analytical method development and validation for impurity profiling and stability testing of active pharmaceutical ingredients (APIs).
• Isotope Dilution Mass Spectrometry (IDMS): Serves as a spike-in standard in IDMS, a gold-standard technique for achieving high metrological accuracy in quantitative analysis.

Basic Information

Product Name	1-Benzhydrylpiperazine-D8
CAS No.	1330188-81-2
Molecular Formula	C17D8H12N2
Molecular Weight	~260.38 g/mol
Synonyms	Benzhydrylpiperazine-d8; 1-(Diphenylmethyl)piperazine-d8; N-(Diphenylmethyl)piperazine-d8; 1-Benzhydrylpiperazine (deuterated); Piperazine, 1-(diphenylmethyl)-, d8; Deuterated Benzhydrylpiperazine; D8-Benzhydrylpiperazine; Internal Standard for Benzhydrylpiperazine
EINECS	Contact for details

Quality Control

Our 1-Benzhydrylpiperazine-D8 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC/NMR), isotopic enrichment (D-content), and identity confirmation. We adhere to relevant industry guidelines for the production of stable labeled compounds to ensure reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container sealed to protect this moisture-sensitive material from atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.