Description

Meperidine-D5 Hydrochloride is a deuterium-labeled internal standard of the analgesic pethidine, essential for precise quantitative analysis in research and development. This high-purity compound is critical for ensuring accuracy and reliability in mass spectrometry-based assays, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by analytical laboratories, pharmaceutical researchers, and forensic toxicologists requiring definitive identification and measurement of meperidine and its metabolites.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the accurate quantification of meperidine in biological matrices such as plasma, serum, and urine.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of the parent drug.
• Forensic and Clinical Toxicology: Enables precise measurement of meperidine levels in forensic analysis and therapeutic drug monitoring (TDM) programs.
• Method Development and Validation: A key component in developing and validating robust, regulatory-compliant analytical methods for laboratories.
• Reference Material for Quality Control: Acts as a certified reference material (CRM) to ensure the accuracy and precision of in-house testing protocols in quality control laboratories.

Basic Information

Product Name	Meperidine-D5 Hydrochloride
CAS No.	1330180-05-6
Molecular Formula	C15H16D5ClNO2
Molecular Weight	287.84 g/mol
Synonyms	Pethidine-D5 Hydrochloride; Isonipecaine-D5 Hydrochloride; Demerol-D5 Hydrochloride; Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate-D5 Hydrochloride; 1-Methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester-D5 hydrochloride; Meperidine-d5 HCl; Pethidine (phenyl-d5) hydrochloride
EINECS	Contact for details

Quality Control

Our Meperidine-D5 Hydrochloride is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic purity (D-enrichment), and chromatographic profile. We adhere to relevant industry standards for reference materials, ensuring reliable and reproducible performance in your sensitive analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.