Description

2-Amino-4-Chloro-n-[(1R,2R)-2-(2,4-Difluorophenyl)-2-Hydroxy-1-Methyl-3-(1H-1,2,4-Triazol-1-Yl)Propyl]Benzamide-D3 is a deuterated isotopologue of a key pharmaceutical intermediate, distinguished by its incorporation of stable deuterium atoms. This deuteration is strategically employed to modify the metabolic profile of active pharmaceutical ingredients, offering significant advantages in drug development and pharmacokinetic studies. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on creating novel therapeutics with improved efficacy and safety profiles.

Application

• Deuterated Drug Development: Serves as a critical precursor in the synthesis of deuterium-labeled active pharmaceutical ingredients (APIs) for metabolic stability studies.
• Pharmacokinetics & Metabolism Research (PK/PD): Used as an internal standard in mass spectrometry for the accurate quantification of parent compounds and metabolites in biological matrices.
• Tracer Studies: Enables detailed investigation of drug absorption, distribution, metabolism, and excretion (ADME) pathways in preclinical and clinical research.
• Reference Standard: Functions as a high-purity certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Antifungal Agent Synthesis: As a deuterated analog of a triazole derivative, it is used in research for developing next-generation antifungal agents with potentially enhanced properties.

Basic Information

Product Name	2-Amino-4-Chloro-n-[(1R,2R)-2-(2,4-Difluorophenyl)-2-Hydroxy-1-Methyl-3-(1H-1,2,4-Triazol-1-Yl)Propyl]Benzamide-D3
CAS No.	1330169-87-3
Molecular Formula	C19H15D3ClF2N5O2
Molecular Weight	424.85 g/mol (deuterated form)
Synonyms	2-Amino-4-chloro-N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]benzamide-d3; Deuterated Isavuconazole Intermediate; (2R,3R)-2-(2,4-Difluorophenyl)-3-(methyl-d3)-4-(1H-1,2,4-triazol-1-yl)butan-2-yl 2-amino-4-chlorobenzoate; Isavuconazole-d3 Related Compound; BAL4815-d3; RO0094815-d3; (1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-d3-3-(1,2,4-triazol-1-yl)propyl 2-amino-4-chlorobenzoate
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C, ²H), HPLC, and LC-MS to confirm structure, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D%), chemical purity, and identification is provided with every shipment, supporting compliance with GMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98.0 atom % D
Deuterium Content (MS)	3 atoms D (min)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.