Description

8-[1,1,2,2,3,3,4,4-Octadeuterio-4-[4-(5-Hydroxypyrimidin-2-Yl)Piperazin-1-Yl]Butyl]-8-Azaspiro[4.5]Decane-7,9-Dione is a deuterated organic compound featuring a complex molecular architecture that combines a spirocyclic dione core with a hydroxypyrimidine-piperazine moiety. This compound is of significant value as a high-purity reference standard and advanced pharmaceutical intermediate, particularly for drug discovery and development programs. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, where its deuterated structure is leveraged for metabolic stability studies and pharmacokinetic research.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Deuterated Reference Standard: Used as an internal standard in quantitative analytical methods like LC-MS and NMR for accurate pharmacokinetic and bioanalytical studies.
• Metabolic Stability Probe: The deuterium labeling aids in studying the metabolic pathways and stability of lead compounds in drug discovery.
• Biochemical Research: Employed in the study of enzyme inhibition and receptor-ligand interactions due to its specific structural motifs.
• Precision Medicine Development: Supports research into targeted therapies where spirocyclic and heterocyclic structures play a crucial role.
• Contract Research & Manufacturing (CRAM): Supplied to organizations requiring custom, high-complexity intermediates for client-specific synthesis projects.

Basic Information

Product Name	8-[1,1,2,2,3,3,4,4-Octadeuterio-4-[4-(5-Hydroxypyrimidin-2-Yl)Piperazin-1-Yl]Butyl]-8-Azaspiro[4.5]Decane-7,9-Dione
CAS No.	1330164-16-3
Molecular Formula	C25H33D8N5O3
Molecular Weight	Contact for details
Synonyms	8-Azaspiro[4.5]decane-7,9-dione, 8-[1,1,2,2,3,3,4,4-octadeuterio-4-[4-(5-hydroxypyrimidin-2-yl)-1-piperazinyl]butyl]-; Deuterated Spirodione-Pyrimidine Derivative; 1330164-16-3; 8-(4-(4-(5-Hydroxypyrimidin-2-yl)piperazin-1-yl)butyl-d8)-8-azaspiro[4.5]decane-7,9-dione; (D8)-Labeled Azaspirodecandione Pyrimidine; Octadeuterated Hydroxypyrimidinylpiperazinylbutyl Azaspirodione
EINECS	Contact for details

Quality Control

Our 8-[1,1,2,2,3,3,4,4-Octadeuterio-4-[4-(5-Hydroxypyrimidin-2-Yl)Piperazin-1-Yl]Butyl]-8-Azaspiro[4.5]Decane-7,9-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (HPLC), deuterium enrichment, and impurity profiles. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Deuterium Enrichment	≥ 98 atom % D
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.