Description

Thioridazine-D3 5-Sulfoxide is a deuterated isotopologue of the thioridazine metabolite, specifically labeled at three positions, making it an essential internal standard for precise quantitative analysis. This compound is critical for ensuring accuracy and reliability in bioanalytical and pharmacokinetic studies by correcting for variations in sample preparation and instrument response. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development and validation for drug metabolism and therapeutic drug monitoring.

Application

• Primary use as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) bioanalysis.
• Quantification of thioridazine and its metabolites in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and pharmacodynamic (PK/PD) studies to understand drug absorption, distribution, metabolism, and excretion.
• Method development and validation in accordance with regulatory guidelines (e.g., FDA, EMA) for bioanalytical assays.
• Supporting research in neuroscience and psychiatry related to phenothiazine-derived antipsychotic agents.
• Quality control and assurance in the manufacturing of active pharmaceutical ingredients (APIs) and finished drug products.

Basic Information

Product Name	Thioridazine-D3 5-Sulfoxide
CAS No.	1330076-56-6
Molecular Formula	C21H23D3N2OS2
Molecular Weight	~ 389.60 g/mol
Synonyms	Thioridazine-d3 Sulfoxide; 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methyl-d3)sulfinylphenothiazine; Thioridazine 5-Sulfoxide-d3; Deuterated Thioridazine Sulfoxide; Thioridazine-d3 S-Oxide; Mellaril-d3 Sulfoxide; 1330076-56-6 (CAS); Thioridazine (methyl-d3) Sulfoxide
EINECS	Contact for details

Quality Control

Our Thioridazine-D3 5-Sulfoxide is manufactured under strict quality management systems to ensure the highest standards of purity and isotopic enrichment. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), chemical purity, isotopic purity (D-enrichment), and residual solvent analysis. We adhere to relevant industry standards for reference materials, supporting GMP and ISO 17025 compliant laboratory practices. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container in a dry, cool, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 99.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.