Description

n-Iso Valerylglycine-D9 is a stable isotope-labeled analog of the amino acid derivative valerylglycine, specifically deuterated at nine positions. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research and development laboratories, clinical diagnostic facilities, and contract research organizations (CROs) engaged in metabolomics, pharmacokinetic studies, and biomarker discovery.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the precise quantification of endogenous valerylglycine and related metabolites in complex biological matrices.
• Biomedical Research & Metabolomics: Enables accurate tracking and measurement of metabolic pathways and flux analysis in studies of inborn errors of metabolism and other metabolic disorders.
• Pharmacokinetics (PK) and Drug Metabolism Studies: Used to determine the absorption, distribution, metabolism, and excretion (ADME) profiles of drug candidates by providing a non-interfering reference signal.
• Clinical Diagnostics: Supports the development and validation of high-sensitivity diagnostic assays for specific metabolic conditions, enhancing test accuracy and reproducibility.
• Stable Isotope Labeling in Chemical Synthesis: Acts as a labeled building block for the synthesis of more complex deuterated molecules for research purposes.
• Quality Control in Reference Material Production: Employed in the calibration and verification of analytical methods and instrumentation within quality control laboratories.

Basic Information

Item	Detail
Product Name	n-Iso Valerylglycine-D9
CAS No.	1330037-21-2
Molecular Formula	C7H4D9NO3
Molecular Weight	~178.23 g/mol
Synonyms	2-[(3-Methylbutanoyl)amino]acetic-2,2,3,4,4,5,5,5-d8 acid-d; Deuterated Valerylglycine; (2,2,3,4,4,5,5,5-Octadeutero-3-methylbutanoyl)glycine-2-d; N-(3-Methyl-1-oxobutyl)glycine-d9; Isoamylglycine-D9; Isovalerylglycine-D9; 3-Methylbutanoylglycine-D9; 2-(Isobutylacetamido)acetic acid-d9
EINECS	Contact for details

Quality Control

Our n-Iso Valerylglycine-D9 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and deuterium enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.