Description

n-Benzyl-n-(2-Chloroethyl)-1-(2,3,4,5,6-Pentadeuteriophenoxy)Propan-2-Amine:Hydrochloride CAS NO 1329838-45-0 is a deuterated derivative of a propan-2-amine hydrochloride, a high-value specialty chemical designed for advanced research and development. This compound is critical for applications requiring isotopic labeling, such as in pharmacokinetic and metabolic studies, where it serves as an internal standard or tracer. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug discovery and analytical method development.

Application

• Isotopic Internal Standard for LC-MS/MS: Used as a deuterium-labeled internal standard in quantitative bioanalytical methods (e.g., HPLC-MS/MS) to ensure accuracy and precision in drug concentration measurements.
• Metabolic Pathway Tracing: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the distribution, biotransformation, and excretion of parent compounds.
• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the calibration and validation of analytical instruments and methods.
• Mechanistic Biochemical Research: Facilitates studies on enzyme mechanisms, receptor binding assays, and other biochemical interactions where non-radioactive isotopic labeling is required.
• Stable Isotope Labeling in Medicinal Chemistry: Used in the synthesis of deuterated drug candidates to potentially alter metabolic profiles and improve pharmacokinetic properties.

Basic Information

Product Name	n-Benzyl-n-(2-Chloroethyl)-1-(2,3,4,5,6-Pentadeuteriophenoxy)Propan-2-Amine:Hydrochloride
CAS No.	1329838-45-0
Molecular Formula	C18H17D5ClNO·HCl
Molecular Weight	Contact for details
Synonyms	1-(2,3,4,5,6-Pentadeuteriophenoxy)-N-benzyl-N-(2-chloroethyl)propan-2-amine hydrochloride; Deuterated Propranolol Analog Hydrochloride; N-Benzyl-N-(2-chloroethyl)-1-(pentadeuteriophenoxy)isopropylamine hydrochloride; [D5]-Phenoxy-labeled amine hydrochloride; 2-[(Benzyl)(2-chloroethyl)amino]-1-(2,3,4,5,6-pentadeuteriophenoxy)propane hydrochloride
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure the highest isotopic purity and chemical integrity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity (by HPLC), isotopic enrichment (by MS), and identity confirmation (by NMR and IR). We adhere to ISO 9001 quality management principles, and our analytical methods are validated to meet the rigorous standards of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.