Description

2-[(2R)-2-Hydroxy-3-[2,3,5,6-Tetradeuterio-4-(3-Oxomorpholin-4-Yl)Anilino]Propyl]Isoindole-1,3-Dione is a high-purity, deuterated chemical intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a stable isotope-labeled building block, enabling precise pharmacokinetic and metabolic studies for new drug candidates. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those focused on developing deuterated drugs and conducting sophisticated ADME (Absorption, Distribution, Metabolism, and Excretion) profiling.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: Serves as a critical labeled precursor in the multi-step synthesis of deuterium-enriched drug molecules.
• Metabolic Pathway Tracing: Used in mass spectrometry-based studies to track and quantify drug metabolites in biological systems with high specificity.
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug concentration over time due to the distinct mass signature of the deuterium atoms.
• Internal Standard Development: Acts as a high-quality internal standard for quantitative bioanalytical assays, improving accuracy and reliability.
• Isotope Effect Research: Facilitates the study of the kinetic isotope effect (KIE) to optimize the stability and efficacy of new therapeutic compounds.
• Proteomics and Biomarker Discovery: Can be utilized in chemical proteomics as a tagged probe for target identification and validation.

Basic Information

Item	Details
Product Name	2-[(2R)-2-Hydroxy-3-[2,3,5,6-Tetradeuterio-4-(3-Oxomorpholin-4-Yl)Anilino]Propyl]Isoindole-1,3-Dione
CAS No.	1329838-35-8
Molecular Formula	C21H18D4N3O5
Molecular Weight	402.44 g/mol
Synonyms	(2R)-2-Hydroxy-3-[2,3,5,6-tetradeuterio-4-(3-oxomorpholin-4-yl)anilino]propyl phthalimide; Deuterated Phthalimide Morpholine Derivative; 4-[4-[[(2R)-2-Hydroxy-3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propyl]amino]-2,3,5,6-tetradeuteriophenyl]morpholin-3-one; 1329838-35-8; (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)-2,3,5,6-tetradeuteriophenyl)amino)propyl)isoindoline-1,3-dione
EINECS	Contact for details

Quality Control

Our deuterated intermediates are produced under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ²H, ¹³C), High-Resolution Mass Spectrometry (HRMS), and HPLC to confirm identity, deuterium incorporation, and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (²H NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.