Description

(2R,4S)-2-[Bis(2-Chloro-2,2-Dideuterioethyl)Amino]-2-Oxo-1,3,2$L^{5}-Oxazaphosphinan-4-Ol is a high-purity, deuterated oxazaphosphinane derivative, a key advanced intermediate in modern pharmaceutical research and development. This compound is specifically engineered to provide enhanced metabolic stability and pharmacokinetic properties in drug discovery programs. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) for the synthesis of novel therapeutic agents, particularly in oncology and targeted therapies. The precise stereochemistry and deuterium labeling make it a critical building block for developing next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of deuterated active pharmaceutical ingredients (APIs) with improved metabolic profiles.
• Drug Discovery & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization, especially in oncology research.
• Isotope Labeling Studies: The deuterium atoms serve as stable isotopic labels for pharmacokinetic (PK), pharmacodynamic (PD), and mass spectrometry-based analytical studies.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for novel therapeutic candidates.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and development of client-specific molecules.
• Academic Research: Used in university and institutional labs for advanced organic synthesis and methodological research involving phosphorus heterocycles.

Basic Information

Item	Details
Product Name	(2R,4S)-2-[Bis(2-Chloro-2,2-Dideuterioethyl)Amino]-2-Oxo-1,3,2$L^{5}-Oxazaphosphinan-4-Ol
CAS No.	1329838-09-6
Molecular Formula	C7H11Cl2D4N2O2P
Molecular Weight	281.12 g/mol (for deuterated form)
Synonyms	(2R,4S)-2-[Bis(2-chloro-2,2-dideuteroethyl)amino]-2-oxo-1,3,2$l^{5}-oxazaphosphinan-4-ol; Deuterated Cyclophosphamide Impurity/Intermediate; (2R,4S)-2-[Bis(2-Chloro-2,2-d2-ethyl)Amino]-2-oxo-1,3,2$l^{5}-oxazaphosphinan-4-ol; 2-[Bis(2-chloro-2,2-dideuterioethyl)amino]-4-hydroxy-1,3,2$l^{5}-oxazaphosphinane 2-oxide, (2R,4S)-; (2R,4S)-4-Hydroxy-2-[bis(2-chloro-2,2-dideuteroethyl)amino]-1,3,2$l^{5}-oxazaphosphinane 2-oxide; Deuterium Labeled Oxazaphosphinane Derivative; CAS 1329838-09-6
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and purity required for pharmaceutical R&D. Our quality system emphasizes identity confirmation via advanced spectroscopic methods (NMR, IR, MS) and purity verification using HPLC. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing specifications for assay, chiral purity, deuterium enrichment, and related substances. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) in a desiccator.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Deuterium Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.