Description

4-[1,1,2,3,3-Pentadeuterio-2-Hydroxy-3-[2-(2-Methoxyphenoxy)Ethylamino]Propoxy]-9H-Carbazol-3-Ol is a deuterated derivative of carvedilol, a non-selective β-blocker and α-1 blocker, designed for advanced pharmaceutical research and development. This compound is critical for conducting metabolic and pharmacokinetic studies, where the deuterium atoms serve as stable, non-radioactive tracers to enhance analytical sensitivity and specificity. It is primarily needed by pharmaceutical R&D laboratories and contract research organizations (CROs) focused on developing and validating novel therapeutic agents and analytical methods.

Application

• Internal Standard for Bioanalytical Assays: Used as a high-purity reference standard in LC-MS/MS and HPLC methods for the quantitative analysis of carvedilol and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Stable Isotope-Labeled Tracer in Clinical Research: Facilitates mass spectrometry-based studies to understand drug-drug interactions and metabolic pathways without radioactive hazards.
• Pharmaceutical Impurity Profiling: Assists in the identification and quantification of process-related impurities and degradation products during drug substance development.
• Method Development and Validation: Serves as a critical component in developing, optimizing, and validating robust analytical methods for regulatory submissions.
• Reference Material for Quality Control: Provides an authenticated standard for in-house quality control testing of active pharmaceutical ingredients (APIs) and finished dosage forms.

Basic Information

Product Name	4-[1,1,2,3,3-Pentadeuterio-2-Hydroxy-3-[2-(2-Methoxyphenoxy)Ethylamino]Propoxy]-9H-Carbazol-3-Ol
CAS No.	1329836-56-7
Molecular Formula	C24H25D5N2O5
Molecular Weight	427.53 g/mol (for C24H25D5N2O5)
Synonyms	Carvedilol-d5; Carvedilol (pentadeuterated); 1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol-d5; (±)-Carvedilol-d5; (RS)-Carvedilol-d5; 4-[1,1,2,3,3-Pentadeuterio-2-hydroxy-3-[[2-(2-methoxyphenoxy)ethyl]amino]propoxy]-9H-carbazol-3-ol; BM 14190-d5
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to relevant ICH guidelines for analytical method validation to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is light-sensitive (store away from light). For long-term storage, consider storing desiccated at -20°C. Keep the container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.