Description

6-Chloro-3-(Piperazin-1-Yl)Benzol[D]Isothiazole-D8 is a deuterated isotopologue of a key benzisothiazole derivative, where eight hydrogen atoms are replaced with deuterium, making it an essential internal standard for quantitative mass spectrometry. This compound is critical for ensuring analytical accuracy and method validation in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in the development and bioanalysis of novel therapeutic agents.

Application

• Use as a stable isotope-labeled internal standard for the precise quantification of its non-deuterated counterpart in biological matrices via LC-MS/MS.
• Critical component in method development and validation for drug metabolism and pharmacokinetics (DMPK) studies to meet regulatory standards (e.g., FDA, EMA).
• Application in deuterium tracing experiments to study metabolic pathways and stability of the parent molecule.
• Essential reference material in pharmaceutical quality control laboratories for impurity profiling and assay development.
• Used in academic and industrial research focusing on benzisothiazole chemistry and its biological activities.

Basic Information

Product Name	6-Chloro-3-(Piperazin-1-Yl)Benzol[D]Isothiazole-D8
CAS No.	1329836-28-3
Molecular Formula	C11H5D8ClN3S
Molecular Weight	Contact for details
Synonyms	6-Chloro-3-(piperazin-1-yl)-1,2-benzisothiazole-D8; 6-Chloro-3-(1-piperazinyl)-1,2-benzisothiazole-D8; 6-Chloro-3-piperazin-1-yl-1,2-benzisothiazole-D8; Benzisothiazole-D8, 6-chloro-3-(1-piperazinyl)-; Deuterated 6-Chloro-3-(Piperazin-1-Yl)Benzisothiazole; [D8]-6-Chloro-3-(piperazin-1-yl)benzisothiazole; CPB-D8; 1329836-28-3
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management to ensure high isotopic purity and chemical integrity, essential for analytical applications. Each batch is characterized by advanced spectroscopic techniques including NMR and Mass Spectrometry. Certificates of Analysis (COA) are provided, detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and identity confirmation. We support compliance with GMP/GLP requirements for reference standard qualification.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (Atom % D)	≥ 98%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.