Description

n-(2-Bromo-6-Fluorophenyl)-4,4,5,5-Tetradeuterio-1H-Imidazol-2-Amine:Hydrochloride is a high-purity, deuterated chemical building block essential for advanced research and development. This compound is specifically valued for its role in creating isotopically labeled analogs, which are critical tools in modern pharmaceutical and agrochemical discovery. It is primarily sought by research scientists and process chemists in the pharmaceutical, biotechnology, and agrochemical industries for applications in drug metabolism studies, pharmacokinetics, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key deuterated synthon for the research and development of new drug candidates, particularly in kinase inhibitor programs.
• Metabolic Tracing: Used in the synthesis of isotopically labeled compounds for mass spectrometry-based drug metabolism and pharmacokinetics (DMPK) studies.
• Agrochemical Research: Serves as a building block in the discovery of novel, labeled pesticides and herbicides to study environmental fate and metabolism.
• Biochemical Probe Development: Utilized to create labeled probes for investigating biological pathways and protein-ligand interactions via techniques like NMR.
• Process Chemistry: Employed in route scouting and optimization for the scalable synthesis of deuterated active pharmaceutical ingredients (APIs).
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	n-(2-Bromo-6-Fluorophenyl)-4,4,5,5-Tetradeuterio-1H-Imidazol-2-Amine:Hydrochloride
CAS No.	1329834-57-2
Molecular Formula	C9H5D4BrFN3·HCl
Molecular Weight	307.57 g/mol (Free base: 271.07 g/mol)
Synonyms	2-Amino-4,4,5,5-tetradeuterio-1H-imidazole, N-(2-bromo-6-fluorophenyl)-, hydrochloride; (2-Bromo-6-fluorophenyl)[(4,4,5,5-2H4)-1H-imidazol-2-yl]amine hydrochloride; N-(2-Bromo-6-fluorophenyl)-1H-imidazol-2-amine-4,4,5,5-d4 hydrochloride; Deuterated Imidazole Amine Hydrochloride; 1329834-57-2; Bromo-fluoro-phenyl deuterated imidazolylamine HCl
EINECS	Contact for details

Quality Control

Every batch of n-(2-Bromo-6-Fluorophenyl)-4,4,5,5-Tetradeuterio-1H-Imidazol-2-Amine:Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic enrichment, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D-content)	≥ 95 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.