Description

4,4,5-Trideuterio-5-[Dideuterio-(2-Methoxyphenoxy)Methyl]-1,3-Dioxolan-2-One is a high-purity, deuterium-labeled derivative of a cyclic carbonate ester. This compound is specifically designed for use as a stable isotope-labeled internal standard or precursor in advanced analytical and synthetic chemistry. It is critically important for researchers and manufacturers requiring precise quantification and metabolic tracking in complex matrices. This material is primarily utilized in pharmaceutical research, agrochemical development, and advanced material science where isotopic purity and structural integrity are paramount.

Application

• Pharmaceutical Research & Development: Serves as a critical deuterium-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate bioanalysis and pharmacokinetic study of active pharmaceutical ingredients (APIs).
• Metabolite Identification & Tracing: Used as a precursor or tracer in drug metabolism and disposition (DMPK) studies to elucidate metabolic pathways and identify metabolites with high specificity.
• Agrochemical Analysis: Employed in the development and validation of analytical methods for the detection and quantification of pesticides, herbicides, and their environmental degradation products.
• Organic Synthesis Intermediate: Acts as a specialized building block for the synthesis of more complex deuterated molecules, enabling the introduction of stable isotopes into target compounds for various research applications.
• Material Science Research: Utilized in the development of novel polymers or specialty materials where deuterium labeling is used to study molecular dynamics, structure, and interactions via techniques like NMR spectroscopy.
• Forensic & Environmental Toxicology: Supports high-accuracy analytical methods for the detection of trace-level contaminants, drugs of abuse, or toxic compounds in forensic and environmental samples.

Basic Information

Product Name	4,4,5-Trideuterio-5-[Dideuterio-(2-Methoxyphenoxy)Methyl]-1,3-Dioxolan-2-One
CAS No.	1329809-21-3
Molecular Formula	C11H9D5O5
Molecular Weight	231.25 g/mol (for deuterated form)
Synonyms	2-Oxo-1,3-dioxolane-5-methanol, 4,4,5-trideuterio-5-[(2-methoxyphenoxy)methyl]-, 5,5-dideuterio-; Deuterated Glycerol Carbonate Guaiacol Ether; 5-[(2-Methoxyphenoxy)methyl]-1,3-dioxolan-2-one-d5; 4,4,5,5',5'-Pentadeuterio-5-[(2-methoxyphenoxy)methyl]-1,3-dioxolan-2-one; Deuterated Cyclic Carbonate Ester; 1329809-21-3; Guaiacol Glycidyl Ether Carbonate-d5
EINECS	Contact for details

Quality Control

Every batch of 4,4,5-Trideuterio-5-[Dideuterio-(2-Methoxyphenoxy)Methyl]-1,3-Dioxolan-2-One is manufactured and controlled under a strict quality management system. Our products undergo rigorous analytical testing, including NMR, HPLC, and MS, to ensure high chemical purity, isotopic enrichment, and structural conformity. Certificates of Analysis (COA) detailing batch-specific results for identity, purity, and isotopic abundance are available upon request. We adhere to cGMP principles for advanced research chemicals to ensure traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.