Description

Antrafenine-D8 Dihydrochloride is a deuterated analog of the non-steroidal anti-inflammatory drug (NSAID) Antrafenine, specifically labeled with eight deuterium atoms. This stable isotope-labeled compound is a critical reference standard and internal standard for precise quantitative analysis in bioanalytical and pharmacokinetic studies. It is essential for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors who require high-fidelity analytical tools for method development, validation, and drug metabolism research.

Application

• Bioanalytical Reference Standard: Serves as a primary standard for calibrating analytical instruments (LC-MS/MS, GC-MS) in quantitative drug assays.
• Pharmacokinetic & Metabolism Studies: Used as an internal standard to accurately measure the concentration of Antrafenine and its metabolites in biological matrices (plasma, serum, urine).
• Drug Impurity Profiling: Aids in the identification and quantification of deuterated impurities or related substances in pharmaceutical formulations.
• Stable Isotope Labeling Research: Employed in mechanistic studies to trace metabolic pathways and understand drug disposition using deuterium isotope effects.
• Regulatory Compliance & Method Validation: Critical for developing and validating analytical methods in compliance with FDA, EMA, and ICH guidelines for new drug applications.

Basic Information

Product Name	Antrafenine-D8 Dihydrochloride
CAS No.	1329809-16-6
Molecular Formula	C₂₈H₂₅D₈Cl₂N₃O₃
Molecular Weight	~528.5 g/mol
Synonyms	1-[2-(7-Methoxy-1-naphthyl)ethyl]-4-(3-methyl-2-butenyl)piperazine-D8 Dihydrochloride; Antrafenine-d8; 1-[2-(7-Methoxynaphthalen-1-yl)ethyl]-4-(3-methylbut-2-en-1-yl)piperazine-d8 Dihydrochloride; Antrafenine (Deuterated); Antrafenine Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Antrafenine-D8 Dihydrochloride is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and isotopic enrichment meet the exacting standards required for analytical applications. A detailed Certificate of Analysis (COA), including results for assay, isotopic purity (D-enrichment), and impurity profile, is supplied with each shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.