Description

5-Chloro-3-(Piperazin-1-Yl)Benzo[D]Isothiazole-D8 is a deuterated analog of a key heterocyclic compound, featuring a stable isotopic label that is essential for advanced analytical and research applications. This high-purity material is critical for use as an internal standard in mass spectrometry, enabling precise quantification and reducing matrix effects in complex sample analysis. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and forensic analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the accurate quantification of its non-deuterated counterpart in bioanalytical assays.
• Drug Metabolism Studies (DMPK): Used in tracing and quantifying parent drugs and metabolites in biological matrices (plasma, urine, tissue) to understand absorption, distribution, metabolism, and excretion (ADME).
• Pharmaceutical R&D: Supports method development and validation in preclinical and clinical research for new chemical entities containing the benzoisothiazole-piperazine scaffold.
• Forensic and Toxicology Analysis: Enables reliable detection and measurement of specific analytes in forensic investigations and toxicological screenings.
• Stable Isotope Labeling: Acts as a building block or reference material in the synthesis of other deuterated compounds for research purposes.

Basic Information

Item	Details
Product Name	5-Chloro-3-(Piperazin-1-Yl)Benzo[D]Isothiazole-D8
CAS No.	1329808-44-7
Molecular Formula	C11H5D8ClN3S
Molecular Weight	Contact for details
Synonyms	5-Chloro-3-(piperazin-1-yl)benzo[d]isothiazole-d8; Deuterated 5-Chloro-3-piperazin-1-yl-1,2-benzisothiazole; 5-Chloro-3-(1-piperazinyl)-1,2-benzisothiazole-d8; Benzo[d]isothiazole-d8, 5-chloro-3-(1-piperazinyl)-; 5-Chloro-3-piperazinylbenzoisothiazole-d8; Stable Isotope Labeled 5-Chloro-3-(Piperazin-1-Yl)Benzisothiazole; Internal Standard for 5-Chloro-3-(Piperazin-1-Yl)Benzo[D]Isothiazole
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C) and high-resolution mass spectrometry (HRMS) to confirm deuteration level and identity. Certificates of Analysis (COA) are provided, detailing specifications for isotopic purity (e.g., D8 ≥ 98%), chemical purity (by HPLC), and other critical parameters relevant for its use as an analytical standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D8)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.