Description

(-)-Normacromerine-D3 is a high-purity, isotopically labeled standard of the natural alkaloid normacromerine, specifically deuterated at three positions. This compound is essential for advanced analytical applications requiring precise quantification and metabolic pathway tracing. It is primarily utilized by research institutions and pharmaceutical development laboratories engaged in pharmacokinetic studies, drug metabolism research, and the development of sensitive LC-MS/MS analytical methods.

Application

• Internal Standard for Quantitative Analysis: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the accurate quantification of normacromerine and related analogs in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used as a tracer in ADME (Absorption, Distribution, Metabolism, and Excretion) studies to investigate the metabolic fate of pharmaceutical compounds.
• Biomedical Research: Facilitates research into the biological activity and mechanism of action of aporphine alkaloids in neurological and pharmacological models.
• Forensic and Clinical Toxicology: Enables the development and validation of highly specific and sensitive assays for detecting alkaloids in forensic or clinical samples.
• Reference Material for Method Development: Provides a stable, well-characterized reference point for developing and calibrating new analytical methodologies in contract research organizations (CROs).

Basic Information

Product Name	(-)-Normacromerine-D3
CAS No.	1329805-62-0
Molecular Formula	C18H18D3NO3
Molecular Weight	~303.4 g/mol
Synonyms	(-)-Normacromerine-d3; 1,2,9,10-Tetramethoxyaporphine-d3; Normacromerine (deuterated); Deuterated Normacromerine; (R)-(-)-Normacromerine-D3; Aporphine Alkaloid-d3; Isotopically Labeled Normacromerine; Internal Standard for Normacromerine
EINECS	Contact for details

Quality Control

Our (-)-Normacromerine-D3 is manufactured under strict quality protocols to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced spectroscopic and chromatographic analyses, including NMR, HPLC, and MS. We ensure consistent batch-to-batch reliability and traceability, meeting the stringent requirements of analytical and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. The product should be stored in a cool, dry place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.