Description

Memantine-D3 Hcl is a deuterium-labeled analog of the NMDA receptor antagonist memantine hydrochloride, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analysis in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the precise quantification of memantine and its metabolites in plasma, serum, and other biological samples.
• Pharmaceutical Research & Development: Supports method development and validation for bioanalytical assays in drug discovery and development pipelines.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug concentration over time to understand absorption, distribution, metabolism, and excretion (ADME).
• Clinical Trial Support: Used in the analysis of samples from clinical trials to monitor drug levels and ensure patient safety and study validity.
• Forensic and Toxicology Testing: Aids in the definitive identification and quantification of memantine in forensic investigations.
• Quality Control in Manufacturing: Serves as a reference standard for impurity profiling and assay validation of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Memantine-D3 Hcl
CAS No.	1329802-06-3
Molecular Formula	C12H18D3N•HCl
Molecular Weight	222.80 g/mol
Synonyms	Memantine-d3 Hydrochloride; 3,5-Dimethyl-1-adamantanamine-d3 Hydrochloride; 1-Amino-3,5-dimethyladamantane-d3 HCl; 3,5-Dimethyladamantan-1-amine-d3 Hydrochloride; Deutrated Memantine HCl; Memantine (methyl-d3) Hydrochloride; NMDA Receptor Antagonist-d3; Akatinol-d3 Hydrochloride
EINECS	Contact for details

Quality Control

Our Memantine-D3 Hcl is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality systems are designed to meet the rigorous demands of pharmaceutical and analytical reference standard users.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Handle with appropriate laboratory precautions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0% (on anhydrous basis)
Isotopic Purity (D3)	≥98.0 atom % D
Chemical Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.