Description

D,L-Mevalonic Acid-D3 Dicyclohexylamine Salt is a deuterium-labeled isotopologue of mevalonic acid, a critical intermediate in the isoprenoid biosynthesis pathway. This high-purity, stable-labeled compound is essential for advanced metabolic and pharmacokinetic studies, providing researchers with a precise internal standard for mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on lipid metabolism, cholesterol biosynthesis, and drug discovery.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial quantitative reference standard in liquid chromatography-tandem mass spectrometry for analyzing mevalonic acid and related metabolites in biological matrices.
• Metabolic Pathway Tracing: Enables detailed investigation of the mevalonate pathway using deuterium tracing techniques to study cholesterol and isoprenoid biosynthesis.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Used in drug development to accurately measure the concentration and turnover of endogenous mevalonic acid following therapeutic intervention.
• Biomarker Research: Facilitates the precise quantification of mevalonic acid as a potential biomarker for metabolic disorders and statin drug efficacy.
• Stable Isotope Dilution Assays (SIDA): Provides the labeled component for highly accurate and sensitive assays to determine endogenous levels of mevalonate.
• Enzyme Activity Assays: Employed in in vitro studies to measure the activity of key enzymes like HMG-CoA reductase.

Basic Information

Product Name	D,L-Mevalonic Acid-D3 Dicyclohexylamine Salt
CAS No.	1329796-98-6
Molecular Formula	C11H20D3NO4
Molecular Weight	230.33 g/mol
Synonyms	Mevalonic Acid-d3 Dicyclohexylamine Salt; (R,S)-Mevalonic Acid-2,4,4-d3 Dicyclohexylammonium Salt; 3,5-Dihydroxy-3-methylpentanoic-2,4,4-d3 Acid Dicyclohexylamine Salt; D,L-Mevalonate-d3 DCHA Salt; 3-Hydroxy-3-methylglutaryl-d3 Reductase Substrate Analog; MVA-d3 Salt; Deuterated Mevalonic Acid Dicyclohexylamine Salt
EINECS	Contact for details

Quality Control

Every batch of D,L-Mevalonic Acid-D3 Dicyclohexylamine Salt is manufactured under strict quality systems and undergoes comprehensive analytical testing to ensure identity, purity, and isotopic enrichment. We provide full traceability and Certificates of Analysis (COA) detailing specifications for chemical purity, isotopic purity (D-enrichment), and residual solvent content. Our quality commitment aligns with the standards expected for high-purity reference materials and pharmaceutical research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.