Description

(R)-(-)-Camptothecin-D5 is a deuterium-labeled analog of the potent topoisomerase I inhibitor, camptothecin. This compound is of critical importance as an internal standard for the precise quantification of camptothecin and its derivatives in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily needed by pharmaceutical research laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical trial sample analysis.

Application

• Bioanalytical Internal Standard: Serves as a critical reference compound for the accurate quantification of camptothecin in plasma, serum, and tissue samples via mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for studying the absorption, distribution, metabolism, and excretion (ADME) profiles of camptothecin-based therapeutics.
• Clinical Research Support: Used in the analysis of patient samples during clinical trials for camptothecin-derived anticancer drugs like irinotecan and topotecan.
• Method Development and Validation: A key component in developing and validating robust, regulatory-compliant (e.g., FDA, EMA) bioanalytical assays.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision analytical techniques to minimize matrix effects and improve data accuracy.
• Metabolite Identification Studies: Aids in the detection and characterization of camptothecin metabolites.

Basic Information

Product Name	(R)-(-)-Camptothecin-D5
CAS No.	1329793-44-3
Molecular Formula	C20H11D5N2O4
Molecular Weight	354.38 g/mol
Synonyms	(R)-20-Deoxycamptothecin-d5; (19R)-Camptothecin-d5; (R)-Camptothecin (phenyl-d5); 4-Deuterio-3,5-bis(deuteriomethyl)benzoic acid (1R)-1,12-dihydroxy-19-ethyl-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-2(11),4,6,8,10,13,15(20),16-octaen-14-one-19-carboxylate; Deuterated (R)-Camptothecin; Camptothecin-D5 (R-enantiomer)
EINECS	Contact for details

Quality Control

Our (R)-(-)-Camptothecin-D5 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing all specifications and test results are provided to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.