Description

n-Benzyl Carvedilol-D5 is a deuterated analog of carvedilol, specifically labeled on the benzyl moiety. This stable isotope-labeled compound is a critical reference standard and internal standard for the precise quantification and metabolic study of carvedilol in complex biological matrices. It is essential for researchers and quality control laboratories in the pharmaceutical and analytical chemistry sectors who require high-fidelity analytical tools. The product ensures accuracy in pharmacokinetic studies, bioanalytical method development, and drug impurity profiling.

Application

• Primary use as an Internal Standard for the accurate quantification of carvedilol via LC-MS/MS and GC-MS methods.
• Metabolic Tracing in ADME (Absorption, Distribution, Metabolism, and Excretion) studies to understand drug pathways.
• Reference material for Bioanalytical Method Development and Validation in clinical and preclinical research.
• Calibration standard for ensuring accuracy in Pharmacokinetic and Pharmacodynamic (PK/PD) studies.
• Critical component in Drug Impurity Profiling and Degradation Studies.
• Used in Isotope Dilution Mass Spectrometry (IDMS) for highest accuracy in quantitative analysis.
• Supporting research in Cardiovascular Drug Development, given carvedilol's role as a β-blocker.

Basic Information

Product Name	n-Benzyl Carvedilol-D5
CAS No.	1329792-68-8
Molecular Formula	C30H31D5N2O4
Molecular Weight	~ 482.64 g/mol
Synonyms	Carvedilol D5 (benzyl-d5); 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol Benzyl-d5 Ester; Deuterated Carvedilol Benzyl Ester; (±)-1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol 2-Benzyl-d5 Acetate; Carvedilol-d5 (benzyl); Carvedilol Benzyl Ester-d5; Carvedilol (benzyl-d5) Internal Standard
EINECS	Contact for details

Quality Control

Every batch of n-Benzyl Carvedilol-D5 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC, NMR, and MS analysis to confirm identity, potency, and deuterium enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. Our quality commitment supports compliance with the rigorous standards required for pharmaceutical reference materials and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Handle and store under inert conditions if the container is opened frequently to minimize potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.