Description

(2R)-5-Deuterio-2,8-Dimethyl-7-(Trideuteriomethyl)-2-[(4R,8R)-4,8,12-Trimethyltridecyl]-3,4-Dihydrochromen-6-Ol is a high-purity, deuterium-labeled analog of a tocopherol (Vitamin E) derivative, designed for advanced research and analytical applications. This compound is critical for use as an internal standard in mass spectrometry and metabolic studies, where its isotopic label provides unmatched accuracy for quantification and tracing. It is essential for pharmaceutical R&D, academic research, and analytical laboratories focused on lipid metabolism, antioxidant research, and drug development.

Application

• Internal Standard for LC-MS/MS: Provides precise quantification of tocopherols and tocotrienols in complex biological matrices like plasma, tissues, and food products.
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of Vitamin E analogs.
• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control and assay validation in drug formulation.
• Nutritional Science Research: Enables accurate measurement of Vitamin E bioavailability and antioxidant status in clinical and preclinical studies.
• Stable Isotope Dilution Assays: Key component in high-accuracy analytical methods for food analysis and supplement potency testing.

Basic Information

Item	Details
Product Name	(2R)-5-Deuterio-2,8-Dimethyl-7-(Trideuteriomethyl)-2-[(4R,8R)-4,8,12-Trimethyltridecyl]-3,4-Dihydrochromen-6-Ol
CAS No.	1329652-13-2
Molecular Formula	C33H53D4O2
Molecular Weight	489.85 g/mol (for C33H53D4O2)
Synonyms	d4-α-Tocopherol (deuterated); 5,7,8-Trimethyl-d4-tocol; Deuterated Vitamin E; (2R)-5-Deutero-2,8-dimethyl-7-(trideuteriomethyl)-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-ol; d4-α-Tocopherol; 2R,4'R,8'R-α-Tocopherol-d4; Stable Isotope Labeled α-Tocopherol
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced and analyzed under strict quality control protocols to ensure isotopic purity and chemical integrity. We provide comprehensive Certificates of Analysis (COA) detailing assay by HPLC, isotopic enrichment (D-content) by NMR or MS, and identification. Our quality system supports compliance with ISO 9001 standards, and materials are suitable for use in GLP/GMP environments upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The container should be kept in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (chemical purity)
Isotopic Purity (MS)	≥ 98 atom % D
Solubility	Soluble in ethanol, DMSO, chloroform; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.