Description

Mebeverine-D6 Hydrochloride is a deuterated isotopologue of the antispasmodic agent Mebeverine, specifically labeled with six deuterium atoms. This high-purity reference standard is essential for precise quantitative analysis in pharmaceutical research and development, ensuring accurate pharmacokinetic and metabolic studies. It is primarily required by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, drug metabolism and pharmacokinetics (DMPK) research, and clinical trial support.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, non-interfering internal standard for the accurate quantification of Mebeverine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in stable isotope tracing experiments to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug.
• Bioanalytical Method Development and Validation: Essential for developing and validating robust, sensitive, and specific analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Enables precise measurement of drug concentration over time, supporting PK/PD modeling and dose optimization studies.
• Clinical Trial Analysis: Supports the bioanalysis phase of clinical trials to determine drug exposure and establish safety and efficacy parameters.
• Forensic and Anti-Doping Analysis: Can be utilized as a reference material in forensic toxicology and sports anti-doping control for the specific identification of Mebeverine.
• Quality Control in Pharmaceutical Manufacturing: Acts as a reference standard for in-process control and final product release testing of Mebeverine hydrochloride formulations.

Basic Information

Product Name	Mebeverine-D6 Hydrochloride
CAS No.	1329647-20-2
Molecular Formula	C25H35D6NO5•HCl
Molecular Weight	482.1 g/mol (approx.)
Synonyms	Mebeverine-d6 HCl; 4-[Ethyl(2-hydroxy-2-phenylethyl-d6)amino]butyl Veratrate Hydrochloride; (RS)-Mebeverine-d6 Hydrochloride; 3,4-Dimethoxybenzoic Acid 4-[Ethyl(2-hydroxy-2-phenylethyl-d6)amino]butyl Ester Hydrochloride; D6-Mebeverine Hydrochloride; Mebeverine (hexadeuterated) Hydrochloride; Mebeverine Internal Standard
EINECS	Contact for details

Quality Control

Our Mebeverine-D6 Hydrochloride is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity (D-enrichment), chemical purity (HPLC), identity confirmation (NMR, MS), and related substances. We adhere to relevant industry standards for reference materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.