Description

(4S)-3-[(2R)-2-[(2R)-2-(2,4-Difluorophenyl)Oxiranyl]-1-Oxopropyl]-4-Benzyl-2-Oxazolidinone-D3 is a high-purity, deuterium-labeled chiral building block and synthetic intermediate. This compound is critical for advanced pharmaceutical research, particularly in the development of deuterated drug candidates where it serves as a key precursor. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for applications in isotope labeling, asymmetric synthesis, and metabolic studies.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: As a chiral synthon for incorporating deuterium into drug molecules to potentially improve metabolic stability and pharmacokinetic profiles.
• Asymmetric Catalysis & Chiral Auxiliary: Utilized in stereoselective synthesis to control the configuration of new stereocenters in complex organic molecules.
• Metabolic Pathway Tracing: Employed as a stable isotope-labeled internal standard in mass spectrometry for quantitative bioanalysis and drug metabolism studies.
• Process Chemistry & Route Scouting: Serves as a high-value intermediate in the research and scale-up of novel synthetic pathways for target compounds.
• Academic & Institutional Research: Used in laboratories focused on organic methodology development, medicinal chemistry, and isotope chemistry.

Basic Information

Product Name	(4S)-3-[(2R)-2-[(2R)-2-(2,4-Difluorophenyl)Oxiranyl]-1-Oxopropyl]-4-Benzyl-2-Oxazolidinone-D3
CAS No.	1329641-35-1
Molecular Formula	C21H16D3F2NO4
Molecular Weight	390.39 g/mol
Synonyms	4-Benzyl-3-[(2R)-2-[(2R)-2-(2,4-difluorophenyl)oxiranyl]-1-oxopropyl]-2-oxazolidinone-d3; (4S)-4-Benzyl-3-[(1R)-1-[(2R)-2-(2,4-difluorophenyl)oxiranyl]carbonyl]-2-oxazolidinone-d3; Deuterated Evans Auxiliary Derivative; (S)-4-Benzyl-3-[(R)-2-((R)-2-(2,4-Difluorophenyl)oxiran-2-yl)-2-oxoethyl]oxazolidin-2-one-d3; (4S)-4-Benzyl-3-[(2R)-2-[(2R)-2-(2,4-Difluorophenyl)oxiran-2-yl]-2-oxoethyl]oxazolidin-2-one-d3; D3-Labeled Chiral Oxazolidinone; 1329641-35-1
EINECS	Contact for details

Quality Control

Our (4S)-3-[(2R)-2-[(2R)-2-(2,4-Difluorophenyl)Oxiranyl]-1-Oxopropyl]-4-Benzyl-2-Oxazolidinone-D3 is manufactured under strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including NMR, HPLC, and MS to ensure high chemical and isotopic purity, as well as enantiomeric excess. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (¹H, ¹³C, ¹⁹F)
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (MS)	≥ 98 atom % D
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.