Description

1'-Benzyl-1,4'-Bipiperidine-4'-Carbonitrile-D10 is a deuterated analog of a key bipiperidine-based chemical intermediate, where ten hydrogen atoms are replaced with deuterium, a stable isotope. This deuteration is critical for enhancing metabolic stability and traceability in research, making it a valuable tool for pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D teams and contract research organizations (CROs) engaged in the development of novel drug candidates, particularly in the areas of neuroscience and receptor-targeted therapies.

Application

• Pharmaceutical Reference Standard: Serves as a certified internal standard for the precise quantification of the non-deuterated parent compound in bioanalytical methods like LC-MS.
• Metabolic Pathway Tracing: Used in Drug Metabolism and Pharmacokinetics (DMPK) studies to track and identify metabolites, leveraging the unique mass shift provided by the deuterium atoms.
• Mechanism of Action (MOA) Research: Employed in preclinical research to investigate drug-receptor interactions and binding kinetics with reduced interference from metabolic degradation.
• Isotope Effect Studies: Facilitates research into the kinetic isotope effect (KIE) to understand reaction mechanisms and improve the design of more stable drug molecules.
• Process Chemistry & Synthesis: Acts as a specialized building block for synthesizing deuterated versions of more complex target molecules for advanced research applications.

Basic Information

Product Name	1'-Benzyl-1,4'-Bipiperidine-4'-Carbonitrile-D10
CAS No.	1329624-69-2
Molecular Formula	C18H15D10N3
Molecular Weight	Contact for details
Synonyms	1'-Benzyl-1,4'-bipiperidine-4'-carbonitrile-d10; 4-Cyano-1'-benzyl-1,4'-bipiperidine-d10; 1-Benzyl-4-cyano-4-phenylpiperidine-d10; Bipiperidine-4-carbonitrile, 1'-benzyl-, deuterated; Deuterated Benzyl Bipiperidine Carbonitrile; [D10]-1'-Benzyl-1,4'-bipiperidine-4'-carbonitrile
EINECS	Contact for details

Quality Control

Every batch of 1'-Benzyl-1,4'-Bipiperidine-4'-Carbonitrile-D10 is synthesized and purified under controlled conditions to ensure high isotopic purity and chemical integrity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment (D%), chemical purity, and identity confirmation are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.