Description

4-Chloro-1-Methylpiperidine-D4 Hydrochloride is a high-purity, deuterium-labeled derivative of a key piperidine building block. This compound is essential for advanced research and development, particularly in the fields of pharmaceutical chemistry and analytical science, where isotopic labeling is required for precise metabolic and pharmacokinetic studies. It serves as a critical intermediate for scientists and manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), development of internal standards for mass spectrometry, and specialized deuterium chemistry applications.

Application

• Deuterated Internal Standard for LC-MS/MS: Used as a quantitative reference standard in bioanalytical methods for accurate drug metabolite profiling and pharmacokinetic studies.
• Pharmaceutical Intermediate: Acts as a key labeled building block in the research and development of novel deuterated drug candidates, potentially enhancing metabolic stability.
• Metabolic Pathway Tracing: Employed in mechanistic studies to track the fate of molecules in biological systems using deuterium as a stable isotopic tracer.
• Chemical Reference Material: Serves as a high-purity certified material for calibration and method validation in analytical laboratories.
• Specialty Synthesis: Utilized in organic synthesis for introducing a deuterated 4-chloro-1-methylpiperidine moiety into more complex molecular architectures.
• NMR Solvent & Reagent: Can be used in nuclear magnetic resonance (NMR) spectroscopy as a specialty reagent or in deuterated solvent studies.

Basic Information

Item	Detail
Product Name	4-Chloro-1-Methylpiperidine-D4 Hydrochloride
CAS No.	1329611-74-6
Molecular Formula	C6H7D4ClN • HCl
Molecular Weight	Contact for details
Synonyms	1-Methyl-4-chloropiperidine-d4 hydrochloride; N-Methyl-4-chloropiperidine-d4 hydrochloride; 4-Chloro-N-methylpiperidine-d4 hydrochloride; (4-Chloro-1-methylpiperidin-1-yl-2,2,6,6-d4)hydrochloride; Deuterated 4-Chloro-N-methylpiperidine HCl; 4-Cl-1-Me-piperidine-d4 HCl; Perdeuterated 4-Chloro-1-methylpiperidine Hydrochloride (on the methyl and ring methylene positions); 4-Chloropiperidine-1-methyl-d4 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-1-Methylpiperidine-D4 Hydrochloride is manufactured and tested under strict quality management systems to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under anhydrous conditions to maintain stability and purity. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.