Description

4'-Chloroacetanilide-13C6 is a stable isotope-labeled analog of 4'-Chloroacetanilide, where six carbon atoms are replaced with the carbon-13 isotope. This compound is critically important as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities for drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and ensuring regulatory compliance in data submission.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the precise and accurate quantification of 4'-Chloroacetanilide and its metabolites in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for tracing metabolic pathways, determining absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to develop robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Pharmaceutical Impurity Profiling and Reference Standard: Acts as a certified reference material for identifying and quantifying process-related impurities or degradation products in active pharmaceutical ingredients (APIs).
• Environmental and Forensic Analysis: Employed in trace analysis for environmental monitoring or forensic toxicology where high specificity is required.
• Isotope Dilution Analysis: Fundamental technique for achieving high-precision measurements in clinical diagnostics and advanced material science.

Basic Information

Product Name	4'-Chloroacetanilide-13C6
CAS No.	1329611-30-4
Molecular Formula	¹³C₆C₂H₈ClNO
Molecular Weight	~175.59 (based on ¹³C substitution)
Synonyms	N-(4-Chlorophenyl)acetamide-13C6; 4-Chloroacetanilide-13C6; p-Chloroacetanilide-13C6; N-Acetyl-4-chloroaniline-13C6; 4'-Chloroacetamilide-13C6; Acetamide, N-(4-chlorophenyl)-13C6; 1-Acetamido-4-chlorobenzene-13C6; (4-Chlorophenyl)acetamide-13C6
EINECS	Contact for details

Quality Control

Every batch of 4'-Chloroacetanilide-13C6 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, verified by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific data for purity, isotopic purity (atom % ¹³C), and solvent content, ensuring full traceability and compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Atom % ¹³C)	≥99%
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.