Description

1,1,2,3,3-Pentadeuterio-3-(2-Methoxyphenoxy)Propane-1,2-Diol is a deuterated derivative of guaifenesin, a compound of significant interest in pharmaceutical research and development. This high-purity labeled compound serves as a critical internal standard and tracer in quantitative mass spectrometry, enabling precise pharmacokinetic and metabolic studies. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in advanced analytical method development and drug discovery.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of guaifenesin and related metabolites in complex biological matrices like plasma, serum, and urine.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to elucidate biotransformation pathways and identify metabolites.
• Stable Isotope Labeled Reference Material: Provides a critical benchmark for method validation, ensuring reliability and reproducibility in analytical assays.
• Pharmaceutical R&D: Supports the development and quality control of new formulations containing expectorant or related pharmacophores.
• Forensic and Clinical Toxicology: Aids in the precise detection and measurement of guaifenesin in specialized diagnostic and forensic applications.

Basic Information

Product Name	1,1,2,3,3-Pentadeuterio-3-(2-Methoxyphenoxy)Propane-1,2-Diol
CAS No.	1329563-41-8
Molecular Formula	C10D5H9O4
Molecular Weight	201.23 g/mol
Synonyms	Guaifenesin-d5; 3-(2-Methoxyphenoxy)-1,2-propanediol-1,1,2,3,3-d5; 1,1,2,3,3-Pentadeuterio-3-(o-methoxyphenoxy)-1,2-propanediol; Deuterated Guaifenesin; [D5]-Guaifenesin; Guaiphenesin-d5; (RS)-3-(2-Methoxyphenoxy)propane-1,2-diol-d5
EINECS	Contact for details

Quality Control

This high-value deuterated standard is manufactured under strict quality control protocols to ensure isotopic purity and chemical integrity. Every batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98% D), chemical purity (by HPLC), and specific analytical data is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms
Isotopic Purity (by MS)	≥98 atom % D
Chemical Purity (HPLC)	≥98.0%
Residual Solvent (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.