Description

2-Methyl-3-Isothiazolone-D3 Hydrochloride is a deuterated isotopologue of a key isothiazolinone biocide, where three hydrogen atoms are replaced with deuterium, making it an invaluable internal standard for precise analytical quantification. This compound is critical for ensuring accuracy and reliability in mass spectrometry and other analytical methods, eliminating matrix effects and providing a stable reference point. It is primarily needed by analytical laboratories, pharmaceutical R&D teams, and chemical manufacturers engaged in method development, quality control, and regulatory compliance testing for biocidal products.

Application

• Primary use as a deuterated internal standard for the accurate quantification of 2-Methyl-3-Isothiazolone (MIT) via LC-MS/MS and GC-MS.
• Method development and validation in analytical chemistry for industrial biocides and preservatives.
• Quality control and assurance in the manufacturing of personal care products (e.g., shampoos, lotions) and paints & coatings to monitor active biocide levels.
• Environmental and residue analysis in water treatment studies and regulatory compliance testing.
• Metabolic and pharmacokinetic studies in pharmaceutical research utilizing deuterium labeling.
• Stability testing and impurity profiling of isothiazolinone-based preservative formulations.

Basic Information

Product Name	2-Methyl-3-Isothiazolone-D3 Hydrochloride
CAS No.	1329509-49-0
Molecular Formula	C4H2D3ClNOS
Molecular Weight	151.63 g/mol (approx.)
Synonyms	2-Methyl-1,2-thiazol-3(2H)-one-d3 hydrochloride; MIT-d3 hydrochloride; 2-Methyl-3(2H)-isothiazolone-d3 HCl; 2-Methyl-4-isothiazolin-3-one-d3 hydrochloride; Deuterated Methylisothiazolinone Hydrochloride; 2-Methyl-δ3-isothiazolone-d3 hydrochloride; Preservative Internal Standard-d3; Kathon CG-d3 (related compound derivative)
EINECS	Contact for details

Quality Control

Every batch of our 2-Methyl-3-Isothiazolone-D3 Hydrochloride is produced and analyzed under strict quality management protocols to ensure the highest isotopic purity and chemical integrity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for isotopic enrichment, chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.