Description

2-Chloro-1-[2-(2-Chloroethylamino)-4,4,5,5-Tetradeuterio-2-Oxo-1,3,2$L^{5}-Oxazaphosphinan-3-Yl]Ethanone CAS NO 1329497-14-4 is a deuterated derivative of a chloroethylamino oxazaphosphinane-based compound, serving as a critical advanced intermediate in pharmaceutical research and development. Its primary value lies in its role as a labeled building block for the synthesis of novel therapeutic agents, enabling detailed metabolic and pharmacokinetic studies through deuterium isotope effects. This high-purity specialty chemical is essential for medicinal chemists and R&D laboratories in the pharmaceutical and biotechnology sectors focused on oncology and targeted drug discovery.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel anticancer agents and targeted therapies.
• Deuterated Building Block: Used in the synthesis of deuterium-labeled drug candidates to study metabolic stability and improve pharmacokinetic profiles.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of new chemical entities in oncology research.
• Isotope Labeling: Serves as a source of deuterium for labeling experiments in drug metabolism and disposition (DMPK) studies.
• Process Chemistry Development: Utilized in route scouting and optimization for the scalable synthesis of complex active pharmaceutical ingredients (APIs).
• Reference Standard: Can be qualified for use as an analytical reference standard in quality control and regulatory submissions.

Basic Information

Product Name	2-Chloro-1-[2-(2-Chloroethylamino)-4,4,5,5-Tetradeuterio-2-Oxo-1,3,2$L^{5}-Oxazaphosphinan-3-Yl]Ethanone
CAS No.	1329497-14-4
Molecular Formula	C7H9D4Cl2N2O3P
Molecular Weight	281.09 g/mol (for deuterated form)
Synonyms	2-Chloro-1-[2-(2-chloroethylamino)-4,4,5,5-tetradeuterio-2-oxo-1,3,2$l^{5}-oxazaphosphinan-3-yl]ethanone; Deuterated Chloroethylamino Oxazaphosphinane Ester; 2-Chloro-1-(2-(2-chloroethylamino)-4,4,5,5-tetradeuterio-2-oxo-1,3,2λ5-oxazaphosphinan-3-yl)ethanone; Tetradeuterated Cyclophosphamide Intermediate; [D4]-Labeled Oxazaphosphorine Derivative; CAS 1329497-14-4
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for research applications. Our quality system includes comprehensive analytical characterization using techniques such as NMR (¹H, ¹³C, ³¹P), HPLC, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity (typically >95% by HPLC), isotopic enrichment, and impurity profile is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Deuterium Enrichment (MS)	≥ 95 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.