Description

[2H3]-Maprotiline Hydrochloride CAS NO 1329496-63-0 is a deuterium-labeled analog of the established tetracyclic antidepressant maprotiline, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is critical for ensuring accuracy and reproducibility in mass spectrometry-based analyses, such as LC-MS/MS, by correcting for instrument variability and matrix effects. It is an essential tool for pharmaceutical researchers, clinical laboratories, and forensic toxicologists engaged in drug metabolism studies, pharmacokinetic research, and therapeutic drug monitoring.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application for quantifying maprotiline and its metabolites in biological matrices (plasma, serum, urine).
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetic (DMPK) studies to track the absorption, distribution, metabolism, and excretion of maprotiline.
• Clinical Toxicology & Therapeutic Drug Monitoring (TDM): Enables precise measurement of maprotiline concentrations in patient samples to optimize dosing and ensure therapeutic efficacy.
• Forensic Analysis: Supports accurate quantification in post-mortem and forensic investigations for legal and diagnostic purposes.
• Bioanalytical Method Development & Validation: Serves as a critical component in developing, validating, and transferring robust analytical protocols to meet regulatory standards (FDA, EMA).
• Metabolite Identification & Profiling: Aids in the structural elucidation and quantification of maprotiline metabolites generated in vitro or in vivo.

Basic Information

Product Name	[2H3]-Maprotiline Hydrochloride
CAS No.	1329496-63-0
Molecular Formula	C20H20D3ClN
Molecular Weight	317.85 g/mol
Synonyms	Deuterated Maprotiline HCl; Maprotiline-d3 Hydrochloride; 1-(3-Methylaminopropyl)dibenzo[b,e]bicyclo[2.2.2]octadiene-d3 Hydrochloride; Ludiomil-d3 HCl; (1RS,12bRS)-1,2,3,4,6,7,12,12b-Octahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine-d3 Hydrochloride; 9,10-Ethanoanthracene-9(10H)-propylamine-d3, N-methyl-, Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of [2H3]-Maprotiline Hydrochloride is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (by HPLC), isotopic enrichment, and other critical parameters to ensure it meets the stringent requirements for use as a certified reference material.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (by MS)	≥99.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.