Description

Chlorpheniramine Nitrile-D6 is a deuterium-labeled analog of a key intermediate in the synthesis of Chlorpheniramine, a widely used antihistamine. This stable isotope-labeled compound is essential for creating internal standards used in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical methods. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism, pharmacokinetic (DMPK) studies, and bioanalytical method development.

Application

• Primary use as an internal standard for the accurate quantification of Chlorpheniramine and its metabolites in biological matrices via LC-MS/MS.
• Critical component in pharmacokinetic (PK) and bioequivalence studies to ensure precise and reliable data.
• Utilized in drug metabolism research to track and quantify drug compounds and their pathways.
• Essential for method development and validation in regulated bioanalytical laboratories.
• Used in the synthesis of other deuterium-labeled compounds for research purposes.
• Supports quality control and assurance in pharmaceutical manufacturing where trace analysis is required.

Basic Information

Product Name	Chlorpheniramine Nitrile-D6
CAS No.	1329488-38-1
Molecular Formula	C16H13D6ClN2
Molecular Weight	274.80 g/mol (for D6 labeled form)
Synonyms	2-[p-Chloro-α-(2-dimethylaminoethyl)benzyl]pyridine-3-carbonitrile-D6; γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanenitrile-D6; Chlorphenamine Nitrile-D6; Chlorpheniramine-d6 Nitrile; Deuterated Chlorpheniramine Nitrile; 3-Pyridinecarbonitrile, 2-[4-chloro-α-[2-(dimethylamino)ethyl]benzyl]-, D6-labeled; (RS)-Chlorpheniramine Nitrile-D6
EINECS	Contact for details

Quality Control

Our Chlorpheniramine Nitrile-D6 is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for its role as an analytical standard. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.