Description

7-Chloro-3-(Piperazin-1-Yl)Benzol[D]Isothiazole-D8 is a deuterated analog of a benzisothiazole derivative, serving as a critical stable isotope-labeled internal standard for precise analytical quantification. This compound is essential for ensuring accuracy and reliability in mass spectrometry-based methods, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers requiring high-fidelity reference materials for method development and validation.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard in Liquid Chromatography-Tandem Mass Spectrometry for the quantitative analysis of its non-deuterated counterpart in biological matrices.
• Pharmacokinetic Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) by minimizing matrix effects and ion suppression.
• Metabolite Identification and Profiling: Assists in the identification and quantification of drug metabolites in complex samples.
• Bioanalytical Method Development and Validation: A key component for developing robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Drug Discovery and Development: Supports preclinical and clinical research by providing reliable data for dose-response and safety assessments.
• Forensic and Doping Control Analysis: Employed in confirmatory testing where high specificity and accuracy are legally mandated.

Basic Information

Product Name	7-Chloro-3-(Piperazin-1-Yl)Benzol[D]Isothiazole-D8
CAS No.	1329488-33-6
Molecular Formula	C11H5D8ClN3S
Molecular Weight	Contact for details
Synonyms	7-Chloro-3-(piperazin-1-yl)-1,2-benzisothiazole-D8; 7-Chloro-3-(1-piperazinyl)-1,2-benzisothiazole-D8; Benzisothiazole-D8, 7-chloro-3-(1-piperazinyl)-; 7-Chloro-3-piperazin-1-yl-1,2-benzisothiazole-D8; Deuterated 7-Chloro-3-(piperazin-1-yl)benzisothiazole; Stable Isotope Labeled 7-Chloro-3-(Piperazin-1-Yl)Benzisothiazole
EINECS	Contact for details

Quality Control

Every batch of 7-Chloro-3-(Piperazin-1-Yl)Benzol[D]Isothiazole-D8 is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, with comprehensive testing including assay, isotopic purity (D-content), and identification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.