Description

n-tert-Butoxycarbonyl 1-(3-Methylbenzyl)Piperazine-D8 is a deuterated derivative of a key piperazine-based building block, specifically designed for advanced research and development applications. This compound is valued for its role as a stable isotope-labeled internal standard, which is critical for ensuring accuracy and reliability in quantitative analytical methods. It is primarily utilized by pharmaceutical researchers, analytical chemists, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and forensic analysis.

Application

• As a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of its non-deuterated counterpart.
• Critical component in drug metabolism and pharmacokinetic (DMPK) studies to track and measure drug candidates and their metabolites in biological matrices.
• Use in bioanalytical method development and validation to enhance specificity, accuracy, and precision in pharmaceutical R&D.
• Application in forensic and clinical toxicology for the precise identification and quantification of specific analytes.
• Tool in mechanistic studies within medicinal chemistry to understand metabolic pathways.
• Synthesis of deuterated analogs of more complex active pharmaceutical ingredients (APIs) for specialized research purposes.

Basic Information

Product Name	n-tert-Butoxycarbonyl 1-(3-Methylbenzyl)Piperazine-D8
CAS No.	1329485-57-5
Molecular Formula	C17H17D8N2O2
Molecular Weight	293.45 g/mol
Synonyms	1-(3-Methylbenzyl)piperazine-1-carboxylic acid tert-butyl ester-D8; Boc-1-(3-Methylbenzyl)piperazine-D8; tert-Butyl 1-[(3-methylphenyl)methyl]-piperazine-1-carboxylate-D8; N-Boc-1-(3-Methylbenzyl)piperazine-D8; 1-(3-Methylbenzyl)-N-Boc-piperazine-D8; Deuterated Boc-3-Methylbenzylpiperazine; Boc-3-MB-Pip-D8; Stable Isotope Labeled Boc Protected Piperazine Derivative
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure high chemical and isotopic purity, which is essential for their function as analytical standards. Each batch is characterized using advanced techniques including NMR, HPLC, and Mass Spectrometry to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) are provided, detailing batch-specific results for assay, isotopic enrichment, and impurity profiles. We adhere to relevant industry guidelines for the production of reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.