Description

7-Cyclopentyl-2-[(5-Piperazin-1-Ylpyridin-2-Yl)Amino]-N,n-Bis(Trideuteriomethyl)Pyrrolo[2,3-D]Pyrimidine-6-Carboxamide CAS NO 1328934-40-2 is a high-purity, deuterated pyrrolopyrimidine derivative designed for advanced research and development. This compound is of significant interest as a key intermediate or reference standard in the synthesis of novel pharmaceutical agents, particularly in oncology and targeted therapies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug discovery and metabolic studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of kinase inhibitors and other targeted small-molecule therapeutics.
• Deuterated Drug Discovery: Used in the development of deuterium-labeled drug candidates to potentially improve metabolic stability, pharmacokinetics, and patent life.
• Biochemical Research: Acts as a tool compound or ligand in enzyme inhibition assays and mechanism-of-action studies.
• Reference Standard: Employed as an analytical standard in HPLC, LC-MS, and NMR for method development, validation, and quality control of active pharmaceutical ingredients (APIs).
• Metabolic Pathway Tracing: The deuterium labels facilitate studies on drug metabolism and disposition using mass spectrometry.
• Preclinical Development: Supports early-stage in vitro and in vivo testing of novel therapeutic candidates.

Basic Information

Product Name	7-Cyclopentyl-2-[(5-Piperazin-1-Ylpyridin-2-Yl)Amino]-N,n-Bis(Trideuteriomethyl)Pyrrolo[2,3-D]Pyrimidine-6-Carboxamide
CAS No.	1328934-40-2
Molecular Formula	C27H34D6N8O
Molecular Weight	498.68 g/mol
Synonyms	7-Cyclopentyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]-N,N-bis(trideuteriomethyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; Deuterated Pyrrolopyrimidine Carboxamide; N,N-Bis(trideuteriomethyl)-7-cyclopentyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; Kinase Inhibitor Intermediate d6; CAS 1328934-40-2
EINECS	Contact for details

Quality Control

Our 7-Cyclopentyl-2-[(5-Piperazin-1-Ylpyridin-2-Yl)Amino]-N,n-Bis(Trideuteriomethyl)Pyrrolo[2,3-D]Pyrimidine-6-Carboxamide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity and isotopic enrichment. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Deuterium Enrichment (LC-MS)	≥ 95 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.