Description

tert-Butyl (5-Iodothiazol-2-Yl)Carbamate is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound matters for its role as a key precursor in the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry and drug discovery programs. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and life science industries for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, especially those containing functionalized thiazole cores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Agrochemical Synthesis: Serves as a precursor in the development of novel pesticides and herbicides with specific biological activity.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target identification.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce diverse functional groups.
• Peptidomimetics and PROTACs: Employed in the synthesis of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) for targeted protein degradation.

Basic Information

Product Name	tert-Butyl (5-Iodothiazol-2-Yl)Carbamate
CAS No.	1326236-62-7
Molecular Formula	C8H11IN2O2S
Molecular Weight	326.15 g/mol
Synonyms	2-((tert-Butoxycarbonyl)amino)-5-iodothiazole; 5-Iodo-2-(((2-methyl-2-propanyl)oxy)carbonyl)amino)thiazole; Boc-5-Iodo-2-aminothiazole; tert-Butyl N-(5-iodo-1,3-thiazol-2-yl)carbamate; 5-Iodo-2-((tert-butoxycarbonyl)amino)thiazole; 2-(Boc-amino)-5-iodothiazole; (5-Iodothiazol-2-yl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (5-Iodothiazol-2-Yl)Carbamate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.