Description

5,5-Dimethyl-4-(4-Methylsulfonylphenyl)-3-[(2,2,3,3-Tetradeuteriocyclopropyl)Methoxy]Furan-2-One is a high-value deuterated chemical intermediate of significant interest in advanced pharmaceutical research and development. Its core value lies in its deuterium-labeled cyclopropyl moiety, which is strategically incorporated to modify the pharmacokinetic and metabolic profiles of drug candidates. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel therapeutic agents, particularly where isotopic labeling is crucial for metabolic stability studies or as a synthetic building block.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of deuterated active pharmaceutical ingredients (APIs) for clinical research.
• Metabolic Stability Studies: Used to create isotopically labeled analogs of drug candidates to study their absorption, distribution, metabolism, and excretion (ADME) properties.
• Proteomics & Biomarker Research: Serves as a precursor for synthesizing specialized reagents or probes used in mass spectrometry-based quantitative analysis.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by providing a deuterium-substituted variant to explore the effects of isotopic substitution on biological activity.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of deuterated target molecules.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in regulatory filings.

Basic Information

Product Name	5,5-Dimethyl-4-(4-Methylsulfonylphenyl)-3-[(2,2,3,3-Tetradeuteriocyclopropyl)Methoxy]Furan-2-One
CAS No.	1325700-11-5
Molecular Formula	C₁₇H₁₈D₄O₅S
Molecular Weight	350.45 g/mol
Synonyms	3-[(2,2,3,3-Tetradeuteriocyclopropyl)methoxy]-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2(5H)-one; Deuterated Cyclopropylmethoxy Furanone Derivative; 5,5-Dimethyl-4-(4-(methylsulfonyl)phenyl)-3-((2,2,3,3-tetradeuteriocyclopropyl)methoxy)furan-2(5H)-one; [D4]-Cyclopropyl Analog; 1325700-11-5; Light-sensitive Furanone Intermediate
EINECS	Contact for details

Quality Control

Our 5,5-Dimethyl-4-(4-Methylsulfonylphenyl)-3-[(2,2,3,3-Tetradeuteriocyclopropyl)Methoxy]Furan-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, suitable for demanding research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC), isotopic enrichment (D-content by NMR or MS), and impurity profiles. We adhere to relevant ICH guidelines for the development and control of novel chemical entities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to maintain stability and prevent any potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Deuterium Content (NMR/MS)	≥ 95 atom % D
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.