Description

(Rs)-2-tert-Butyl-D9-Amino-1-(2-Chlorophenyl)Ethanol Hydrochloride is a high-purity, deuterated chiral intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly where isotopic labeling is required for metabolic or pharmacokinetic studies. This compound is essential for medicinal chemists and process development scientists working in pharmaceutical, biotechnology, and contract research organizations focused on central nervous system (CNS) and adrenergic receptor-targeting therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of deuterated analogs of β-adrenergic receptor antagonists and related active pharmaceutical ingredients (APIs).
• Metabolic Tracer Development: Used in the preparation of isotopically labeled compounds for drug metabolism and pharmacokinetics (DMPK) studies, leveraging the deuterium (D9) label.
• Process Chemistry & Route Scouting: Serves as a key intermediate in the research and development of efficient, scalable synthetic routes for complex chiral molecules.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in pharmaceutical analysis, ensuring batch-to-batch consistency.
• Medicinal Chemistry Research: Facilitates structure-activity relationship (SAR) studies by enabling the synthesis of specifically deuterated derivatives to probe biological activity and stability.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of clinical trial materials and niche APIs.

Basic Information

Product Name	(Rs)-2-tert-Butyl-D9-Amino-1-(2-Chlorophenyl)Ethanol Hydrochloride
CAS No.	1325559-14-5
Molecular Formula	C₁₂H₁₀D₉Cl₂NO
Molecular Weight	278.22 g/mol (for monoisotopic mass)
Synonyms	(R,S)-2-(tert-Butyl-D9-amino)-1-(2-chlorophenyl)ethanol hydrochloride; 1-(2-Chlorophenyl)-2-[(1,1-dimethylethyl-D9)amino]ethanol hydrochloride (racemic); rac-2-(tert-Butyl-D9-amino)-1-(2-chlorophenyl)ethan-1-ol hydrochloride; Deuterated Labetalol Intermediate; D9-tert-Butylamino Chlorophenylethanol Hydrochloride; (RS)-1-(2-Chlorophenyl)-2-(tert-butyl-D9-amino)ethanol HCl; 2-Chlorophenyl D9-tert-butylaminoethanol Hydrochloride
EINECS	Contact for details

Quality Control

Our (Rs)-2-tert-Butyl-D9-Amino-1-(2-Chlorophenyl)Ethanol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and isotopic enrichment verification, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing comprehensive specifications are provided with every shipment to guarantee traceability, consistency, and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (RS ratio)
Deuterium Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.