Description

2-[2,2,3,3,5,5,6,6-Octadeuterio-4-[3-[2-(Trifluoromethyl)Phenothiazin-10-Yl]Propyl]Piperazin-1-Yl]Ethanol is a deuterated analog of a trifluoromethylphenothiazine derivative, designed for advanced research and development applications. This compound is of significant value as a stable isotope-labeled internal standard or tracer in quantitative analytical methods, enhancing the precision and reliability of data. It is primarily required by pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) engaged in pharmacokinetic studies, metabolic profiling, and method development for related active pharmaceutical ingredients.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled internal standard in liquid chromatography-tandem mass spectrometry for the accurate quantification of its non-deuterated counterpart in biological matrices.
• Metabolic Pathway Tracing: Employed in drug metabolism and pharmacokinetics (DMPK) studies to trace and identify metabolites, leveraging the isotopic mass shift.
• Pharmaceutical R&D: Serves as a critical reference material in the research and development of novel phenothiazine-derived therapeutics.
• Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., ICH, FDA).
• Biomarker Analysis: Facilitates precise measurement in proteomic or metabolomic research where high specificity is required.
• Quality Control Reference: Acts as a certified reference standard for in-house quality control testing of active pharmaceutical ingredients (APIs) and finished drug products.

Basic Information

Product Name	2-[2,2,3,3,5,5,6,6-Octadeuterio-4-[3-[2-(Trifluoromethyl)Phenothiazin-10-Yl]Propyl]Piperazin-1-Yl]Ethanol
CAS No.	1323633-98-2
Molecular Formula	C22H17D8F3N3OS
Molecular Weight	Contact for details
Synonyms	10-[3-[4-(2-Hydroxyethyl)-1-piperazinyl]propyl]-2-(trifluoromethyl)phenothiazine-d8; Deuterated Trifluoperazine Metabolite Standard; 2-(Trifluoromethyl)-10H-phenothiazine-d8 ethanol piperazine derivative; N-Deuterated Ethanol, 2-[4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazinyl]-; Deuterated TFPZ metabolite; d8-Labelled Phenothiazine Derivative; Stable Isotope Labeled Internal Standard 1323633-98-2
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as isotopic purity, chemical purity, and identity confirmation. We adhere to stringent protocols suitable for research and analytical reference material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.