Description

trans-[2-(4-tert-Butyloxycarbonylamino)Cyclohexyloxy]Tetrahydro-2H-Pyran-D5 is a deuterated, Boc-protected amino alcohol derivative, serving as a sophisticated building block in advanced organic synthesis. This compound is valued for its role in introducing stable isotope labels and chiral, protected amino functionalities into target molecules, which is critical for research in medicinal chemistry and analytical method development. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of deuterated drug candidates, metabolic studies, and high-value specialty chemicals.

Application

• Deuterated Pharmaceutical Intermediate: A key synthon for the incorporation of deuterium atoms into novel drug molecules to potentially improve metabolic stability, pharmacokinetics, and patent life.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and as a building block for probing biological pathways using deuterium as a non-radioactive tracer.
• Isotope-Labeled Standard: Serves as an internal standard in quantitative mass spectrometry (LC-MS/MS) for the accurate bioanalysis of pharmaceuticals and their metabolites.
• Chiral Synthesis: The trans-configured cyclohexyl ring and protected amino group make it a valuable precursor for the synthesis of enantiomerically pure compounds.
• Peptidomimetics & PROTACs Development: Utilized in constructing complex molecular architectures such as peptide mimics and proteolysis-targeting chimeras (PROTACs).
• Advanced Material Science: Potential application in the synthesis of specialty polymers and liquid crystals where isotopic purity and specific stereochemistry are required.

Basic Information

Product Name	trans-[2-(4-tert-Butyloxycarbonylamino)Cyclohexyloxy]Tetrahydro-2H-Pyran-D5
CAS No.	1322626-69-6
Molecular Formula	C16H24D5NO4
Molecular Weight	~306.43 g/mol
Synonyms	trans-4-[(Tetrahydro-2H-pyran-2-yl)oxy]-D5-cyclohexanamine, N-Boc derivative; (1R,4R)-4-[(Tetrahydro-2H-pyran-2-yl)oxy]-D5-cyclohexanamine, N-Boc-protected; Boc-trans-4-(THP-oxy)-D5-cyclohexylamine; trans-N-Boc-4-(Tetrahydro-2-pyranyloxy)-D5-cyclohexylamine; Deuterated Boc-Amino-THP-Protected Cyclohexanol; 1322626-69-6; Boc-NH-trans-4-(THPO)-D5-Cy
EINECS	Contact for details

Quality Control

Our trans-[2-(4-tert-Butyloxycarbonylamino)Cyclohexyloxy]Tetrahydro-2H-Pyran-D5 is manufactured under controlled conditions to ensure high chemical and isotopic purity, meeting the stringent requirements of research and development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay (HPLC/NMR), deuterium enrichment, enantiomeric excess, and impurity profile. We adhere to a rigorous quality management system, and specifications can be aligned with client-specific protocols for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and should be handled under inert atmosphere when appropriate to maintain stability and prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Deuterium Enrichment (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.