Description

cis-[2-(4-tert-Butyloxycarbonylamino)Cyclohexyloxy]Tetrahydro-2H-Pyran-D5 is a deuterated, Boc-protected amino alcohol derivative, serving as a sophisticated chiral building block and advanced intermediate in organic synthesis. Its core value lies in enabling precise isotopic labeling and stereochemical control, which is critical for mechanistic studies and the development of compounds with enhanced metabolic stability. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly those focused on deuterium-enriched active ingredients and novel therapeutic agents.

Application

• Deuterated Pharmaceutical Intermediate: Key synthon for the synthesis of deuterium-labeled drug candidates to improve pharmacokinetic profiles (e.g., metabolic stability, half-life).
• Chiral Building Block: Used in asymmetric synthesis to construct complex molecules with defined stereochemistry for active pharmaceutical ingredients (APIs).
• Metabolic Pathway Tracer: Employed in research and development for isotopic labeling studies to elucidate drug metabolism and degradation pathways.
• Agrochemical Research: Intermediate in the development of novel, isotopically-labeled pesticides and herbicides for enhanced efficacy and environmental studies.
• Peptidomimetic Synthesis: Useful for introducing protected amino-alcohol motifs into peptide analogs and other bioactive compounds.
• Material Science Research: Potential precursor for specialized polymers or liquid crystals where isotopic purity and specific chirality are required.

Basic Information

Product Name	cis-[2-(4-tert-Butyloxycarbonylamino)Cyclohexyloxy]Tetrahydro-2H-Pyran-D5
CAS No.	1322626-64-1
Molecular Formula	C16H24D5NO4
Molecular Weight	298.43 g/mol (for deuterated form)
Synonyms	Boc-D5-Amino-THP Ether; (1S,2R)-2-((Tetrahydro-2H-pyran-2-yl)oxy)cyclohexanamine-1,2,2,3,3-d5 N-Boc; cis-2-((Tetrahydro-2H-pyran-2-yl)oxy)cyclohexanamine-1,2,2,3,3-d5 N-Boc; tert-Butyl ((1S,2R)-2-((tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl-1,2,2,3,3-d5)carbamate; Deuterated Boc-Protected THP-Amino Cyclohexanol; N-Boc-cis-2-(Tetrahydro-2H-pyran-2-yloxy)cyclohexylamine-d5
EINECS	Contact for details

Quality Control

Our cis-[2-(4-tert-Butyloxycarbonylamino)Cyclohexyloxy]Tetrahydro-2H-Pyran-D5 is manufactured under strict quality control protocols to ensure high chemical and isotopic purity, meeting the stringent requirements for advanced synthetic intermediates. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay (HPLC/NMR), deuterium enrichment, enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable, ensuring reliable supply and batch-to-batch consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Deuterium Enrichment (NMR/MS)	≥ 95 atom % D
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.